The cells in the human body are continuously challenged by a variety of genotoxic attacks.
Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

The p53 gene is frequently inactivated in human cancers. Here we have isolated a p53-
inducible gene, p53R2, by using differential display to examine messenger RNAs in a …

Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against
cancer. Rational and effective use of its killing power depends on understanding IR …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity. In
normal cells the MDM2 protein binds to the p53 protein and maintains p53 at low levels by …

Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …

Abstract p53 mutants that lack DNA-binding activities, and therefore, transcriptional
activities, are among the most common mutations in human cancer. Recently, a new role for …

Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair,
recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced …

In human cells, efficient global genomic repair of DNA damage induced by ultraviolet
radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 …