Accessibility of human oocytes for research poses a serious ethical challenge to society.
This fact categorically holds true when pursuing some of the most promising areas of …

Interspecies somatic cell nuclear transfer (iSCNT) has the capacity to rescue endangered
species, ethically produce human embryonic stem cells, and allow for more specific analysis …

The hypothesis that high concentrations of IGF1 can impair embryo development was
investigated in a bovine in vitro model to reflect conditions in polycystic ovary syndrome …

More than a decade has now passed since the birth of the first endangered species
produced from an adult somatic cell reprogrammed by somatic cell nuclear transfer. At that …

Inter-species somatic cell nuclear transfer (iSCNT) embryos usually fail to develop to the
blastocyst stage and beyond due to incomplete reprogramming of donor cell. We evaluated …

Although transforming growth factor alpha (TGF-alpha) is known to be an important survival
factor for granulosa cells, the cellular and molecular mechanisms involved are uncertain …

Bacterial cell walls contain peptidoglycan (PTG), which, among other actions, induces fever.
The present experiment evaluated the effects of PTG treatment on early pregnancy and …

To artificially activate embryos in somatic cell nuclear transfer (SCNT), chemical treatment
with ionomycin has been used to induce transient levels of Ca2+ and initiate reprogramming …

Initially, development of the zygote is under control of the oocyte ooplasm. However, it is
presently unknown if and to what extent is the ooplasm able to interact with a transferred …

Interspecies somatic cell nuclear transfer (iSCNT) offers the possibility of preserving
endangered species. Handmade cloning (HMC) has proved to be an efficient alternative to …