Anesthesia and developing brains: unanswered questions and proposed paths forward

C Ing, DO Warner, LS Sun, RP Flick… - Obstetric Anesthesia …, 2022 - journals.lww.com
Optimizing surgical technique is an important part of improving outcomes in cesarean
delivery. It is unclear whether uterine exteriorization is associated with hemostasis benefits …

Does general anesthesia affect neurodevelopment in infants and children?

ME McCann, SG Soriano - Bmj, 2019 - bmj.com
General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised …

ME McCann, JC De Graaff, L Dorris, N Disma… - The Lancet, 2019 - thelancet.com
Background In laboratory animals, exposure to most general anaesthetics leads to
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …

[PDF][PDF] GAS, PANDA, and MASK

L Vutskits, DJ Culley - Anesthesiology, 2019 - access.archive-ouverte.unige.ch
Two decades ago, the possibility that anesthetics could harm the developing brain was
identified in rodents. 1 This work has been replicated in multiple species, including …

[HTML][HTML] Best practice & research clinical anesthesiology: safety and quality in perioperative anesthesia care. Update on safety in pediatric anesthesia

JC De Graaff, MF Johansen, M Hensgens… - Best Practice & …, 2021 - Elsevier
Pediatric anesthesia is large part of anesthesia clinical practice. Children, parents and
anesthesiologists fear anesthesia because of the risk of acute morbidity and mortality …

Controversies in anesthesia-induced developmental neurotoxicity

N Useinovic, V Jevtovic-Todorovic - Best Practice & Research Clinical …, 2023 - Elsevier
Advances in the field of pediatric anesthesiology have enabled the performance of complex
and life-saving procedures with minimal patient discomfort. However, preclinical studies …

Play simulation for children in magnetic resonance imaging

CJ Heales, E Lloyd - Journal of Medical Imaging and Radiation Sciences, 2022 - Elsevier
Abstract Introduction Magnetic Resonance Imaging (MRI) can be a challenging examination,
particularly for children. The aim of this Clinical Perspective is to outline early experiences …

Neurotoxicity of general anesthetics in children: evidence and uncertainties

DC Bellinger, J Calderon - Current Opinion in Pediatrics, 2019 - journals.lww.com
Given that approximately half of the anesthetic exposures in young US children are 1 h or
less in duration, the results of the recent clinical studies are reassuring. Because of the …

Is anesthesia bad for the brain? Current knowledge on the impact of anesthetics on the developing brain

SG Soriano, ME McCann - Anesthesiology Clinics, 2020 - anesthesiology.theclinics.com
Concerns about long-term anesthetic-induced neurotoxicity have permeated the pediatric
anesthesia community since landmark laboratory reports demonstrated neurodegeneration …

Neurotoxicity of anesthesia in children: prevention and treatment

AE Vinson, CS Houck - Current treatment options in neurology, 2018 - Springer
Purpose of review The purpose of this review is to summarize the current evidence
regarding the impact of the exposure to anesthetic and sedative agents on …