Understudied proteins: opportunities and challenges for functional proteomics

G Kustatscher, T Collins, AC Gingras, T Guo… - Nature …, 2022 - nature.com
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …

Proximity labeling in plants

SL Xu, R Shrestha, SS Karunadasa… - Annual review of plant …, 2023 - annualreviews.org
Proteins are workhorses in the cell; they form stable and more often dynamic, transient
protein–protein interactions, assemblies, and networks and have an intimate interplay with …

A multi-omics integrative network map of maize

L Han, W Zhong, J Qian, M Jin, P Tian, W Zhu… - Nature …, 2023 - nature.com
Networks are powerful tools to uncover functional roles of genes in phenotypic variation at a
system-wide scale. Here, we constructed a maize network map that contains the genomic …

A phase-separated nuclear GBPL circuit controls immunity in plants

S Huang, S Zhu, P Kumar, JD MacMicking - Nature, 2021 - nature.com
Liquid–liquid phase separation (LLPS) has emerged as a central paradigm for
understanding how membraneless organelles compartmentalize diverse cellular activities in …

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

PC Havugimana, RK Goel, S Phanse, A Youssef… - Nature …, 2022 - nature.com
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous
macromolecular networks on a proteome scale, but current methods are experimentally …

[HTML][HTML] Integrating multi-omics data for crop improvement

F Scossa, S Alseekh, AR Fernie - Journal of plant physiology, 2021 - Elsevier
Our agricultural systems are now in urgent need to secure food for a growing world
population. To meet this challenge, we need a better characterization of plant genetic and …

m6A readers ECT2/ECT3/ECT4 enhance mRNA stability through direct recruitment of the poly(A) binding proteins in Arabidopsis

P Song, L Wei, Z Chen, Z Cai, Q Lu, C Wang, E Tian… - Genome biology, 2023 - Springer
Background RNA N 6-methyladenosine (m6A) modification is critical for plant growth and
crop yield. m6A reader proteins can recognize m6A modifications to facilitate the functions of …

Metabolons, enzyme–enzyme assemblies that mediate substrate channeling, and their roles in plant metabolism

Y Zhang, AR Fernie - Plant Communications, 2021 - cell.com
Metabolons are transient multi-protein complexes of sequential enzymes that mediate
substrate channeling. They differ from multi-enzyme complexes in that they are dynamic …

WheatOmics: A platform combining multiple omics data to accelerate functional genomics studies in wheat

S Ma, M Wang, J Wu, W Guo, Y Chen, G Li, Y Wang… - Molecular plant, 2021 - cell.com
Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-
omics data have revolutionized the research strategies of functional genomics in wheat …

Plant proteome dynamics

J Mergner, B Kuster - Annual Review of Plant Biology, 2022 - annualreviews.org
Proteins are intimately involved in executing and controlling virtually all cellular processes.
To understand the molecular mechanisms that underlie plant phenotypes, it is essential to …