Both genetic and epigenetic mechanisms intimately regulate cancer development and
chemoresistance. Different genetic alterations are observed in multiple genes, and most are …

Overexpression of MYC is a hallmark of many human cancers. The MYC oncogene has long
been thought to execute its neoplastic functions by acting as a classic transcription factor …

Osteoporosis is a highly prevalent disease which has been a major public health problem
and considered to be associated with chronic low-grade systemic inflammation and …

Low back pain (LBP) is a common worldwide disease that causes an enormous social
economic burden. Intervertebral disc degeneration (IDD) is considered as a major cause of …

The activity of protein kinases IKK-ε and TANK-binding kinase 1 (TBK1) has been shown to
be associated with inflammatory diseases. As an inhibitor of IKK-ε and TBK1, amlexanox is …

MYC is a proto-oncogene regulating a large number of genes involved in a plethora of
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …

Epoxyeicosatrienoic acids (EETs) are products of arachidonic acid metabolism catalyzed by
cytochrome P450 epoxygenases. These small molecules are autocrine and paracrine lipid …

In addition to oncogenic MYC translocations, Burkitt lymphoma (BL) depends on the
germinal centre (GC) dark zone (DZ) B cell survival and proliferation programme, which is …

The loosening of implants is an important clinical issue, particularly for patients with
osteoporosis. In these patients, an implant should preferably both promote osteoblast …

Recent advances have highlighted profound roles of FOXO transcription factors, especially
FOXO1, in bone development and remodeling. The regulation of bone development by …