Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
Cell-type-specific alternative polyadenylation promotes oncogenic gene expression in non-small cell lung cancer progression
Disrupted alternative polyadenylation (APA) is frequently involved in tumorigenesis and
cancer progression by regulating the gene expression of oncogenes and tumor …
cancer progression by regulating the gene expression of oncogenes and tumor …
Sites of Cre‐recombinase activity in mouse lines targeting skeletal cells
ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …
function and gain‐of‐function studies, as well as lineage tracing, through gene …
The emerging roles of CFIm25 (NUDT21/CPSF5) in human biology and disease
CP Masamha - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
The mammalian cleavage factor I subunit CFIm25 (NUDT21) binds to the UGUA sequences
of precursor RNAs. Traditionally, CFIm25 is known to facilitate 3′ end formation of pre …
of precursor RNAs. Traditionally, CFIm25 is known to facilitate 3′ end formation of pre …
Targeting osteocytes vs osteoblasts
Y Kitase, M Prideaux - Bone, 2023 - Elsevier
Although osteoblasts and osteocytes are descended from the same lineage, they each have
unique and essential roles in bone. Targeting gene deletion to osteoblasts and osteocytes …
unique and essential roles in bone. Targeting gene deletion to osteoblasts and osteocytes …
NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
Purpose Gliomas and their surrounding microenvironment constantly interact to promote
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …
TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation
S Wei, X Huang, Q Zhu, T Chen, Y Zhang… - Cell Death & …, 2024 - nature.com
Chronic kidney disease (CKD) is a major global health concern and the third leading cause
of premature death. Renal fibrosis is the primary process driving the progression of CKD, but …
of premature death. Renal fibrosis is the primary process driving the progression of CKD, but …
[HTML][HTML] Alternative polyadenylation writer CSTF2 forms a positive loop with FGF2 to promote tubular epithelial-mesenchymal transition and renal fibrosis
Y Tan, T Zheng, R Zhang, S Chen, Q Cheng… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Effective therapies for renal fibrosis, the common endpoint for most kidney diseases, are
lacking. We previously reported that alternative polyadenylation (APA) drives transition from …
lacking. We previously reported that alternative polyadenylation (APA) drives transition from …
[HTML][HTML] PolyAMiner-Bulk is a deep learning-based algorithm that decodes alternative polyadenylation dynamics from bulk RNA-seq data
Alternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism; yet, its
regulation and impact on human diseases remain understudied. Existing bulk RNA …
regulation and impact on human diseases remain understudied. Existing bulk RNA …