Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Z Chen, F Han, Y Du, H Shi, W Zhou - Signal transduction and targeted …, 2023 - nature.com
Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
[HTML][HTML] Combination therapy in combating cancer
RB Mokhtari, TS Homayouni, N Baluch… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …
Atezolizumab-bevacizumab plus Y-90 TARE for the treatment of hepatocellular carcinoma: preclinical rationale and ongoing clinical trials
A Di Federico, A Rizzo, R Carloni… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The treatment algorithm of advanced hepatocellular carcinoma (HCC) has
evolved since the introduction of immunotherapy. The IMbrave150 trial set atezolizumab …
evolved since the introduction of immunotherapy. The IMbrave150 trial set atezolizumab …
Effects of ionizing radiation on biological molecules—mechanisms of damage and emerging methods of detection
Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …
series of events that are amplified by endogenous signaling and culminating in oxidative …
Normalization of the vasculature for treatment of cancer and other diseases
New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization
The purpose of this review is to present the current state of the role of imaging in
photodynamic therapy (PDT). For the reader to fully appreciate the context of the discussions …
photodynamic therapy (PDT). For the reader to fully appreciate the context of the discussions …
Role of angiogenesis in tumor growth and metastasis
J Folkman - Seminars in oncology, 2002 - Elsevier
Angiogenesis is required for invasive tumor growth and metastasis and constitutes an
important point in the control of cancer progression. Its inhibition may be a valuable new …
important point in the control of cancer progression. Its inhibition may be a valuable new …
Vascular endothelial growth factor and angiogenesis
ANN Hoeben, B Landuyt, MS Highley, H Wildiers… - Pharmacological …, 2004 - ASPET
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …
Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy
TWH Meijer, JHAM Kaanders, PN Span, J Bussink - Clinical cancer research, 2012 - AACR
Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …
oxidative stress. However, malignant tumors vary in their response to irradiation as a …