Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones
MP Mayer, LM Gierasch - Journal of Biological Chemistry, 2019 - ASBMB
Hsp70 chaperones are central hubs of the protein quality control network and collaborate
with co-chaperones having a J-domain (an∼ 70-residue–long helical hairpin with a flexible …
with co-chaperones having a J-domain (an∼ 70-residue–long helical hairpin with a flexible …
The Hsp70-chaperone machines in bacteria
MP Mayer - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The ATP-dependent Hsp70s are evolutionary conserved molecular chaperones that
constitute central hubs of the cellular protein quality surveillance network. None of the other …
constitute central hubs of the cellular protein quality surveillance network. None of the other …
Learning protein constitutive motifs from sequence data
Statistical analysis of evolutionary-related protein sequences provides information about
their structure, function, and history. We show that Restricted Boltzmann Machines (RBM) …
their structure, function, and history. We show that Restricted Boltzmann Machines (RBM) …
Large-scale identification of coevolution signals across homo-oligomeric protein interfaces by direct coupling analysis
Proteins have evolved to perform diverse cellular functions, from serving as reaction
catalysts to coordinating cellular propagation and development. Frequently, proteins do not …
catalysts to coordinating cellular propagation and development. Frequently, proteins do not …
Metazoan Hsp70-based protein disaggregases: emergence and mechanisms
NB Nillegoda, B Bukau - Frontiers in molecular biosciences, 2015 - frontiersin.org
Proteotoxic stresses and aging cause breakdown of cellular protein homeostasis, allowing
misfolded proteins to form aggregates, which dedicated molecular machines have evolved …
misfolded proteins to form aggregates, which dedicated molecular machines have evolved …
Computational analysis of residue interaction networks and coevolutionary relationships in the Hsp70 chaperones: A community-hopping model of allosteric …
G Stetz, GM Verkhivker - PLoS Computational Biology, 2017 - journals.plos.org
Allosteric interactions in the Hsp70 proteins are linked with their regulatory mechanisms and
cellular functions. Despite significant progress in structural and functional characterization of …
cellular functions. Despite significant progress in structural and functional characterization of …
Dynamical structures of Hsp70 and Hsp70-Hsp40 complexes
Protein misfolding and aggregation are pathological events that place a significant amount
of stress on the maintenance of protein homeostasis (proteostasis). For prevention and …
of stress on the maintenance of protein homeostasis (proteostasis). For prevention and …
Inter-residue, inter-protein and inter-family coevolution: bridging the scales
H Szurmant, M Weigt - Current opinion in structural biology, 2018 - Elsevier
Highlights•Coevolutionary modeling has an immense potential in structural systems
biology.•Interaction between two protein families can be detected.•Specific interaction …
biology.•Interaction between two protein families can be detected.•Specific interaction …
Machine learning for evolutionary-based and physics-inspired protein design: Current and future synergies
Computational protein design facilitates the discovery of novel proteins with prescribed
structure and functionality. Exciting designs were recently reported using novel data-driven …
structure and functionality. Exciting designs were recently reported using novel data-driven …
Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness
Potts Hamiltonian models of protein sequence co-variation are statistical models constructed
from the pair correlations observed in a multiple sequence alignment (MSA) of a protein …
from the pair correlations observed in a multiple sequence alignment (MSA) of a protein …