Nanomedicines to deliver mRNA: state of the art and future perspectives
I Gómez-Aguado, J Rodríguez-Castejón… - Nanomaterials, 2020 - mdpi.com
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its
unique features compared to plasmid DNA: Transient expression, no need to enter into the …
unique features compared to plasmid DNA: Transient expression, no need to enter into the …
Codon optimization in the production of recombinant biotherapeutics: potential risks and considerations
VP Mauro - BioDrugs, 2018 - Springer
Biotherapeutics are increasingly becoming the mainstay in the treatment of a variety of
human conditions, particularly in oncology and hematology. The production of therapeutic …
human conditions, particularly in oncology and hematology. The production of therapeutic …
[HTML][HTML] Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs
S Seneff, G Nigh, AM Kyriakopoulos… - Food and Chemical …, 2022 - Elsevier
Abstract The mRNA SARS-CoV-2 vaccines were brought to market in response to the public
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …
health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious …
Codon and codon-pair usage tables (CoCoPUTs): facilitating genetic variation analyses and recombinant gene design
A Alexaki, J Kames, DD Holcomb, J Athey… - Journal of molecular …, 2019 - Elsevier
Usage of sequential codon-pairs is non-random and unique to each species. Codon-pair
bias is related to but clearly distinct from individual codon usage bias. Codon-pair bias is …
bias is related to but clearly distinct from individual codon usage bias. Codon-pair bias is …
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
A Alexaki, GK Hettiarachchi, JC Athey, UK Katneni… - Scientific reports, 2019 - nature.com
Synonymous codons occur with different frequencies in different organisms, a phenomenon
termed codon usage bias. Codon optimization, a common term for a variety of approaches …
termed codon usage bias. Codon optimization, a common term for a variety of approaches …
Codon usage regulates human KRAS expression at both transcriptional and translational levels
KRAS and HRAS are highly homologous oncogenic Ras GTPase family members that are
mutated in a wide spectrum of human cancers. Despite having high amino acid identity …
mutated in a wide spectrum of human cancers. Despite having high amino acid identity …
Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps
Many large proteins suffer from slow or inefficient folding in vitro. It has long been known that
this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the …
this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the …
Synonymous variants that disrupt messenger RNA structure are significantly constrained in the human population
Background The role of synonymous single-nucleotide variants in human health and
disease is poorly understood, yet evidence suggests that this class of “silent” genetic …
disease is poorly understood, yet evidence suggests that this class of “silent” genetic …
SARS-CoV-2 codon usage bias downregulates host expressed genes with similar codon usage
Severe acute respiratory syndrome has spread quickly throughout the world and was
declared a pandemic by the World Health Organization (WHO). The pathogenic agent is a …
declared a pandemic by the World Health Organization (WHO). The pathogenic agent is a …
The functional consequences of the novel ribosomal pausing site in SARS-CoV-2 spike glycoprotein RNA
The SARS-CoV-2 Spike glycoprotein (S protein) acquired a unique new 4 amino acid-PRRA-
insertion sequence at amino acid residues (aa) 681–684 that forms a new furin cleavage …
insertion sequence at amino acid residues (aa) 681–684 that forms a new furin cleavage …