[HTML][HTML] Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds
G Zhu, T Zhang, M Chen, K Yao, X Huang, B Zhang… - Bioactive materials, 2021 - Elsevier
Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …
approaches, autologous and allogeneic bone grafting have not achieved the ideal …
Extracellular signaling molecules to promote fracture healing and bone regeneration
KD Hankenson, K Gagne, M Shaughnessy - Advanced drug delivery …, 2015 - Elsevier
To date, the delivery of signaling molecules for bone regeneration has focused primarily on
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …
[HTML][HTML] Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders
Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …
Biomaterials act as enhancers of growth factors in bone regeneration
R Chen, J Wang, C Liu - Advanced Functional Materials, 2016 - Wiley Online Library
Inspired by the physiological events of the “wound healing cascade”, the integration of
biomaterials and growth factors is generally accepted as an emerging and powerful strategy …
biomaterials and growth factors is generally accepted as an emerging and powerful strategy …
PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling
A Li, X Xia, J Yeh, H Kua, H Liu, Y Mishina, A Hao, B Li - PloS one, 2014 - journals.plos.org
Platelet-derived growth factors (PDGFs) play important roles in skeletal development and
bone fracture healing, yet how PDGFs execute their functions remains incompletely …
bone fracture healing, yet how PDGFs execute their functions remains incompletely …
Matrix Gla protein promotes the bone formation by up-regulating Wnt/β-catenin signaling pathway
J Zhang, Z Ma, K Yan, Y Wang, Y Yang… - Frontiers in …, 2019 - frontiersin.org
Objective: Studies suggest that matrix Gla protein (MGP) is associated with osteoporosis.
However, the precise mechanism through which MGP regulates bone metabolism is not fully …
However, the precise mechanism through which MGP regulates bone metabolism is not fully …
Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene
J Costa-Rodrigues, MH Fernandes, O Pinho… - The Journal of nutritional …, 2018 - Elsevier
Lycopene is a lipid-soluble pigment that is mainly found in tomato. It is the carotenoid that
presents the highest antioxidant potential, and due to that, it has been implicated in a …
presents the highest antioxidant potential, and due to that, it has been implicated in a …
Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
A Sebastian, NR Hum, DK Murugesh, S Hatsell… - PLoS …, 2017 - journals.plos.org
Wnt3a is a major regulator of bone metabolism however, very few of its target genes are
known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and …
known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and …
Endothelial YAP1 in regenerative lung growth through the angiopoietin–Tie2 pathway
T Mammoto, M Muyleart, A Mammoto - American Journal of …, 2019 - atsjournals.org
Angiogenesis, the formation of new blood capillaries, plays a key role in organ development
and regeneration. Inhibition of lung angiogenesis through the blockade of angiogenic …
and regeneration. Inhibition of lung angiogenesis through the blockade of angiogenic …
Osteopontin promotes oncostatin M production in human osteoblasts: implication of rheumatoid arthritis therapy
CM Su, YC Chiang, CY Huang, CJ Hsu… - The Journal of …, 2015 - journals.aai.org
Accumulating evidence indicates that subchondral bone might play an essential role in
rheumatoid arthritis (RA). Osteopontin (OPN) induces the production of an important …
rheumatoid arthritis (RA). Osteopontin (OPN) induces the production of an important …