[HTML][HTML] Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

G Zhu, T Zhang, M Chen, K Yao, X Huang, B Zhang… - Bioactive materials, 2021 - Elsevier
Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Extracellular signaling molecules to promote fracture healing and bone regeneration

KD Hankenson, K Gagne, M Shaughnessy - Advanced drug delivery …, 2015 - Elsevier
To date, the delivery of signaling molecules for bone regeneration has focused primarily on
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …

[HTML][HTML] Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

R Vlashi, X Zhang, M Wu, G Chen - Genes & Diseases, 2023 - Elsevier
Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Biomaterials act as enhancers of growth factors in bone regeneration

R Chen, J Wang, C Liu - Advanced Functional Materials, 2016 - Wiley Online Library
Inspired by the physiological events of the “wound healing cascade”, the integration of
biomaterials and growth factors is generally accepted as an emerging and powerful strategy …

PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling

A Li, X Xia, J Yeh, H Kua, H Liu, Y Mishina, A Hao, B Li - PloS one, 2014 - journals.plos.org
Platelet-derived growth factors (PDGFs) play important roles in skeletal development and
bone fracture healing, yet how PDGFs execute their functions remains incompletely …

Matrix Gla protein promotes the bone formation by up-regulating Wnt/β-catenin signaling pathway

J Zhang, Z Ma, K Yan, Y Wang, Y Yang… - Frontiers in …, 2019 - frontiersin.org
Objective: Studies suggest that matrix Gla protein (MGP) is associated with osteoporosis.
However, the precise mechanism through which MGP regulates bone metabolism is not fully …

Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene

J Costa-Rodrigues, MH Fernandes, O Pinho… - The Journal of nutritional …, 2018 - Elsevier
Lycopene is a lipid-soluble pigment that is mainly found in tomato. It is the carotenoid that
presents the highest antioxidant potential, and due to that, it has been implicated in a …

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

A Sebastian, NR Hum, DK Murugesh, S Hatsell… - PLoS …, 2017 - journals.plos.org
Wnt3a is a major regulator of bone metabolism however, very few of its target genes are
known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and …

Endothelial YAP1 in regenerative lung growth through the angiopoietin–Tie2 pathway

T Mammoto, M Muyleart, A Mammoto - American Journal of …, 2019 - atsjournals.org
Angiogenesis, the formation of new blood capillaries, plays a key role in organ development
and regeneration. Inhibition of lung angiogenesis through the blockade of angiogenic …

Osteopontin promotes oncostatin M production in human osteoblasts: implication of rheumatoid arthritis therapy

CM Su, YC Chiang, CY Huang, CJ Hsu… - The Journal of …, 2015 - journals.aai.org
Accumulating evidence indicates that subchondral bone might play an essential role in
rheumatoid arthritis (RA). Osteopontin (OPN) induces the production of an important …