Inflammation: the link between comorbidities, genetics, and Alzheimer's disease

EA Newcombe, J Camats-Perna, ML Silva… - Journal of …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

RY Li, Q Qin, HC Yang, YY Wang, YX Mi, YS Yin… - Molecular …, 2022 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Biomarkers of nutrition and health: new tools for new approaches

C Picó, F Serra, AM Rodríguez, J Keijer, A Palou - Nutrients, 2019 - mdpi.com
A main challenge in nutritional studies is the valid and reliable assessment of food intake, as
well as its effects on the body. Generally, food intake measurement is based on self-reported …

[HTML][HTML] Emerging roles of SIRT1 in fatty liver diseases

RB Ding, J Bao, CX Deng - International journal of biological …, 2017 - ncbi.nlm.nih.gov
Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …

Chronic inflammation—A link between nonalcoholic fatty liver disease (NAFLD) and dysfunctional adipose tissue

M Petrescu, SI Vlaicu, L Ciumărnean, MV Milaciu… - Medicina, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a new challenge in modern medicine, due to its
high prevalence in the world. The pathogenesis of NAFLD is a complex dysmetabolic …

Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by …

H Zhuang, X Yao, H Li, Q Li, C Yang, C Wang… - Brain, behavior, and …, 2022 - Elsevier
High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

[HTML][HTML] Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal …

J Hong, Y Jia, S Pan, L Jia, H Li, Z Han, D Cai… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Dietary supplementation of butyrate can prevent diet-induced obesity through increasing
mitochondrial function in mice, yet the up-stream signaling pathway remains elusive. In this …

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease

Y Luo, H Lin - Immunity, Inflammation and Disease, 2021 - Wiley Online Library
Low‐level of chronic inflammation activation is characteristic of obesity. Nonalcoholic fatty
liver disease (NAFLD) is closely linked to obesity and is an emerging health problem, it …

FGF21 attenuates high-fat diet-induced cognitive impairment via metabolic regulation and anti-inflammation of obese mice

Q Wang, J Yuan, Z Yu, LI Lin, Y Jiang, Z Cao… - Molecular …, 2018 - Springer
Accumulating studies suggest that overnutrition-associated obesity may lead to
development of type 2 diabetes mellitus and metabolic syndromes (MetS). MetS and its …

Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

S Hamamah, A Amin, AL Al-Kassir, J Chuang… - Nutrients, 2023 - mdpi.com
Obesity is a multifactorial disease that continues to increase in prevalence worldwide.
Emerging evidence has shown that the development of obesity may be influenced by …