Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …

Data from the Women's Health Study show that serum levels of growth-differentiation factor-
15 (GDF-15), a distant member of the transforming growth factor-β superfamily, are an …

Mammalian skeletal muscles are composed of a variety of highly specialized fibers whose
selective recruitment allows muscles to fulfill their diverse functional tasks. In addition …

Structural remodelling occurring before, due to the underlying heart disease, and during
atrial fibrillation (AF) sets the stage for permanent AF. Current therapy in AF aims to maintain …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Calcium (Ca2+) dysregulation is a hallmark of heart failure and is characterized by impaired
Ca2+ sequestration into the sarcoplasmic reticulum (SR) by the SR-Ca2+-ATPase (SERCA) …

Early investigations in the late 1890s and early 1900s documented cardiac enlargement in
athletes with above-normal exercise capacity and no evidence of cardiovascular disease …