[HTML][HTML] Immune-checkpoint inhibitors: long-term implications of toxicity
The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
[HTML][HTML] Immune-related adverse events and the balancing act of immunotherapy
The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which
involve diverse organs, have varying biology, onset time, and severity. Herein, we identify …
involve diverse organs, have varying biology, onset time, and severity. Herein, we identify …
Harnessing big data to characterize immune-related adverse events
Immune-checkpoint inhibitors (ICIs) have transformed patient care in oncology but are
associated with a unique spectrum of organ-specific inflammatory toxicities known as …
associated with a unique spectrum of organ-specific inflammatory toxicities known as …
[HTML][HTML] Society for Immunotherapy of Cancer (SITC) consensus definitions for immune checkpoint inhibitor-associated immune-related adverse events (irAEs) …
Immune-related adverse events (irAEs) associated with immune checkpoint inhibitor (ICI)
therapy may vary substantially in their clinical presentation, including natural history …
therapy may vary substantially in their clinical presentation, including natural history …
Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity
While the spectrum of neurological immune checkpoint inhibitor-related adverse events is
expanding, patients' outcomes are not well documented. This study aimed to assess …
expanding, patients' outcomes are not well documented. This study aimed to assess …
[HTML][HTML] Autoantibody profiles in patients with immune checkpoint inhibitor-induced neurological immune related adverse events
L Müller-Jensen, S Knauss, L Ginesta Roque… - Frontiers in …, 2023 - frontiersin.org
Background Neurological immune-related adverse events (irAE-n) are severe and
potentially fatal toxicities of immune checkpoint inhibitors (ICI). To date, the clinical …
potentially fatal toxicities of immune checkpoint inhibitors (ICI). To date, the clinical …
[HTML][HTML] Paraneoplastic neurological syndromes of the central nervous system: pathophysiology, diagnosis, and treatment
L Marsili, S Marcucci, J LaPorta, M Chirra, AJ Espay… - Biomedicines, 2023 - mdpi.com
Paraneoplastic neurological syndromes (PNS) include any symptomatic and non-metastatic
neurological manifestations associated with a neoplasm. PNS associated with antibodies …
neurological manifestations associated with a neoplasm. PNS associated with antibodies …
[HTML][HTML] Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: a retrospective multicentre cohort …
L Müller-Jensen, S Zierold, JM Versluis… - European Journal of …, 2022 - Elsevier
Aim Immune checkpoint inhibitor-induced encephalitis (ICI-iE) is a rare but life-threatening
toxicity of immune checkpoint inhibitor treatment. We aim to identify the characteristics of ICI …
toxicity of immune checkpoint inhibitor treatment. We aim to identify the characteristics of ICI …
Anti-Hu antibodies in patients with neurologic side effects of immune checkpoint inhibitors
A Farina, M Villagrán-García… - Neurology …, 2022 - AAN Enterprises
Background and Objectives To clinically characterize post–immune checkpoint inhibitor (ICI)
Hu antibody (Ab) neurologic disorders, we analyzed Hu-Ab–positive patients with …
Hu antibody (Ab) neurologic disorders, we analyzed Hu-Ab–positive patients with …
Population-based epidemiology study of paraneoplastic neurologic syndromes
Objectives Population-based epidemiologic data for paraneoplastic neurologic syndromes
(PNSs) in the United States are lacking. Our objective was to evaluate the incidence …
(PNSs) in the United States are lacking. Our objective was to evaluate the incidence …