[HTML][HTML] Immune-checkpoint inhibitors: long-term implications of toxicity

DB Johnson, CA Nebhan, JJ Moslehi… - Nature Reviews Clinical …, 2022 - nature.com
The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …

[HTML][HTML] Immune-related adverse events and the balancing act of immunotherapy

M Conroy, J Naidoo - Nature communications, 2022 - nature.com
The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which
involve diverse organs, have varying biology, onset time, and severity. Herein, we identify …

Harnessing big data to characterize immune-related adverse events

Y Jing, J Yang, DB Johnson, JJ Moslehi… - Nature Reviews Clinical …, 2022 - nature.com
Immune-checkpoint inhibitors (ICIs) have transformed patient care in oncology but are
associated with a unique spectrum of organ-specific inflammatory toxicities known as …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) consensus definitions for immune checkpoint inhibitor-associated immune-related adverse events (irAEs) …

J Naidoo, C Murphy, MB Atkins… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Immune-related adverse events (irAEs) associated with immune checkpoint inhibitor (ICI)
therapy may vary substantially in their clinical presentation, including natural history …

Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity

A Farina, C Birzu, MH Elsensohn, A Picca… - Brain …, 2023 - academic.oup.com
While the spectrum of neurological immune checkpoint inhibitor-related adverse events is
expanding, patients' outcomes are not well documented. This study aimed to assess …

[HTML][HTML] Autoantibody profiles in patients with immune checkpoint inhibitor-induced neurological immune related adverse events

L Müller-Jensen, S Knauss, L Ginesta Roque… - Frontiers in …, 2023 - frontiersin.org
Background Neurological immune-related adverse events (irAE-n) are severe and
potentially fatal toxicities of immune checkpoint inhibitors (ICI). To date, the clinical …

[HTML][HTML] Paraneoplastic neurological syndromes of the central nervous system: pathophysiology, diagnosis, and treatment

L Marsili, S Marcucci, J LaPorta, M Chirra, AJ Espay… - Biomedicines, 2023 - mdpi.com
Paraneoplastic neurological syndromes (PNS) include any symptomatic and non-metastatic
neurological manifestations associated with a neoplasm. PNS associated with antibodies …

[HTML][HTML] Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: a retrospective multicentre cohort …

L Müller-Jensen, S Zierold, JM Versluis… - European Journal of …, 2022 - Elsevier
Aim Immune checkpoint inhibitor-induced encephalitis (ICI-iE) is a rare but life-threatening
toxicity of immune checkpoint inhibitor treatment. We aim to identify the characteristics of ICI …

Anti-Hu antibodies in patients with neurologic side effects of immune checkpoint inhibitors

A Farina, M Villagrán-García… - Neurology …, 2022 - AAN Enterprises
Background and Objectives To clinically characterize post–immune checkpoint inhibitor (ICI)
Hu antibody (Ab) neurologic disorders, we analyzed Hu-Ab–positive patients with …

Population-based epidemiology study of paraneoplastic neurologic syndromes

S Shah, EP Flanagan, P Paul, CY Smith… - Neurology …, 2021 - AAN Enterprises
Objectives Population-based epidemiologic data for paraneoplastic neurologic syndromes
(PNSs) in the United States are lacking. Our objective was to evaluate the incidence …