Impact of microplastics and nanoplastics on human health

MSL Yee, LW Hii, CK Looi, WM Lim, SF Wong, YY Kok… - Nanomaterials, 2021 - mdpi.com
Plastics have enormous impacts to every aspect of daily life including technology, medicine
and treatments, and domestic appliances. Most of the used plastics are thrown away by …

Emergence of nanoplastic in the environment and possible impact on human health

R Lehner, C Weder, A Petri-Fink… - … science & technology, 2019 - ACS Publications
On account of environmental concerns, the fate and adverse effects of plastics have
attracted considerable interest in the past few years. Recent studies have indicated the …

Non-viral vectors for gene-based therapy

H Yin, RL Kanasty, AA Eltoukhy, AJ Vegas… - Nature reviews …, 2014 - nature.com
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

[HTML][HTML] Upconversion nanoparticles: design, nanochemistry, and applications in theranostics

G Chen, H Qiu, PN Prasad, X Chen - Chemical reviews, 2014 - ACS Publications
Theranostics is a concept of integrating imaging and therapy into a single platform for use in
the next generation of personalized medicine to meet the challenges in modern health …

Delivery materials for siRNA therapeutics

R Kanasty, JR Dorkin, A Vegas, D Anderson - Nature materials, 2013 - nature.com
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …

PEG—A versatile conjugating ligand for drugs and drug delivery systems

A Kolate, D Baradia, S Patil, I Vhora, G Kore… - Journal of controlled …, 2014 - Elsevier
Polyethylene glycol (PEG) conjugation is a rapidly evolving strategy to solve hurdles in
therapeutic delivery and is being used as an add-on tool to the traditional drug delivery …

Nanoparticle PEGylation for imaging and therapy

JV Jokerst, T Lobovkina, RN Zare, SS Gambhir - Nanomedicine, 2011 - Taylor & Francis
Nanoparticles are an essential component in the emerging field of nanomedical imaging
and therapy. When deployed in vivo, these materials are typically protected from the immune …

Molecular imaging with theranostic nanoparticles

JV Jokerst, SS Gambhir - Accounts of chemical research, 2011 - ACS Publications
Nanoparticles (NPs) offer diagnostic and therapeutic capabilities not available with small
molecules or microscale tools. As the field of molecular imaging has emerged from the …

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

JE Zuckerman, CHJ Choi, H Han… - Proceedings of the …, 2012 - National Acad Sciences
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-
based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from …

A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics

S Ranjbar, X Zhong, J Manautou, X Lu - Advanced Drug Delivery Reviews, 2023 - Elsevier
Small interfering RNAs (siRNAs) are among the most promising therapeutic platforms in
many life-threatening diseases. Owing to the significant advances in siRNA design, many …