Impact of microplastics and nanoplastics on human health
Plastics have enormous impacts to every aspect of daily life including technology, medicine
and treatments, and domestic appliances. Most of the used plastics are thrown away by …
and treatments, and domestic appliances. Most of the used plastics are thrown away by …
Emergence of nanoplastic in the environment and possible impact on human health
On account of environmental concerns, the fate and adverse effects of plastics have
attracted considerable interest in the past few years. Recent studies have indicated the …
attracted considerable interest in the past few years. Recent studies have indicated the …
Non-viral vectors for gene-based therapy
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …
[HTML][HTML] Upconversion nanoparticles: design, nanochemistry, and applications in theranostics
Theranostics is a concept of integrating imaging and therapy into a single platform for use in
the next generation of personalized medicine to meet the challenges in modern health …
the next generation of personalized medicine to meet the challenges in modern health …
Delivery materials for siRNA therapeutics
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
PEG—A versatile conjugating ligand for drugs and drug delivery systems
A Kolate, D Baradia, S Patil, I Vhora, G Kore… - Journal of controlled …, 2014 - Elsevier
Polyethylene glycol (PEG) conjugation is a rapidly evolving strategy to solve hurdles in
therapeutic delivery and is being used as an add-on tool to the traditional drug delivery …
therapeutic delivery and is being used as an add-on tool to the traditional drug delivery …
Nanoparticle PEGylation for imaging and therapy
Nanoparticles are an essential component in the emerging field of nanomedical imaging
and therapy. When deployed in vivo, these materials are typically protected from the immune …
and therapy. When deployed in vivo, these materials are typically protected from the immune …
Molecular imaging with theranostic nanoparticles
JV Jokerst, SS Gambhir - Accounts of chemical research, 2011 - ACS Publications
Nanoparticles (NPs) offer diagnostic and therapeutic capabilities not available with small
molecules or microscale tools. As the field of molecular imaging has emerged from the …
molecules or microscale tools. As the field of molecular imaging has emerged from the …
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
JE Zuckerman, CHJ Choi, H Han… - Proceedings of the …, 2012 - National Acad Sciences
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-
based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from …
based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from …
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Small interfering RNAs (siRNAs) are among the most promising therapeutic platforms in
many life-threatening diseases. Owing to the significant advances in siRNA design, many …
many life-threatening diseases. Owing to the significant advances in siRNA design, many …