Recombination is a key molecular mechanism that has profound implications on both micro-
and macroevolutionary processes. However, the determinants of recombination rate …

Meiotic cells introduce numerous programmed DNA double-strand breaks (DSBs) into their
genome to stimulate crossover recombination. DSB numbers must be high enough to …

ORFanage is a system designed to assign open reading frames (ORFs) to known and novel
gene transcripts while maximizing similarity to annotated proteins. The primary intended use …

Large, whole-genome sequencing (WGS) data sets containing families provide an important
opportunity to identify crossovers and shared genetic material in siblings. However, the high …

Meiotic recombination landscapes differ greatly between distantly and closely related taxa,
populations, individuals, sexes, and even within genomes; however, the factors driving this …

Steady-state expression quantitative trait loci (eQTLs) explain only a fraction of disease-
associated loci identified through genome-wide association studies (GWASs), while eQTLs …

Gaining a better understanding of rates and patterns of meiotic recombination is crucial for
improving evolutionary genomic modelling, with applications ranging from demographic to …

The last couple of decades have highlighted the importance of studying hybridization,
particularly among primate species, as it allows us to better understand our own …

Motivation Meiotic recombination is the main driving force of human genetic diversity, along
with mutations. Recombinations split into crossovers, separating large chromosomal regions …

Genome sequencing and genetic mapping of molecular markers have demonstrated nearly
complete Y-linkage across much of the guppy (Poecilia reticulata) XY chromosome pair …