Drugs are generally converted to biologically inactive forms and eliminated from the body,
principally by hepatic metabolism. However, certain drugs undergo biotransformation to …

Liver toxicity is one of the most relevant adverse effects of antiretroviral therapy. Within the
non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz can be considered a …

Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause
liver disease. Most cases of DILI are benign, and improve after drug withdrawal. It is …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Background Data on adverse drug reactions (ADRs) related to antiretroviral (ARV) use in
public health practice are few indicating the need for ART safety surveillance in clinical care …

The decline in approval of new drugs during the past decade has led to a close analysis of
the drug discovery process. One of the main reasons for attrition is preclinical toxicity …

Human immunodeficiency virus-infected patients on antiretroviral drug therapy frequently
experience hepatotoxicity, the underlying mechanism of which is poorly understood …

Purpose To assess the nature, severity, predictability and preventability of adverse drug
reactions (ADRs) and to identify risk factors for antiretroviral ADRs. Methods Enrolled …

Objectives Epidemiologic data of HIV and viral hepatitis coinfection are needed in sub-
Saharan Africa to guide health policy for hepatitis screening and optimized antiretroviral …

HEPATOTOXICITY IN PATIENTS PRESCRIBED EFAVIRENZ OR NEVIRAPINE Page 1 EU RO
PE AN JOUR NAL OF MED I CAL RE SEARCH 343 Abstract Aim: For several years …