Many bacteria are naturally competent, able to actively transport environmental DNA
fragments across their cell envelope and into their cytoplasm. Because incoming DNA …

Classical methods for the study of bacterial pathogens have proven to be inadequate to
inform with respect to chronic infections including those associated with arthroplasties …

Nontypeable Haemophilus influenzae (NTHi) exclusively colonize and infect humans and
are critical to the pathogenesis of chronic obstructive pulmonary disease (COPD). In vitro …

Background Many bacteria can take up DNA, but the evolutionary history and function of
natural competence and transformation remain obscure. The sporadic distribution of …

The human-restricted bacterium Haemophilus influenzae is responsible for respiratory
infections in both children and adults. While colonization begins in the upper airways, it can …

Biofilms formed by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity,
recurrence, and resistance to treatment of multiple human respiratory tract diseases …

Natural competence for DNA uptake is common among bacteria but its evolutionary function
is controversial. Resolving the dispute requires a detailed understanding of both how cells …

Background Cefepime and aztreonam are highly efficacious against H. influenzae, and
resistant strains are rare. In this study, we isolated cefepime-and aztreonam-nonsusceptible …

Many bacteria are able to efficiently bind and take up double-stranded DNA fragments, and
the resulting natural transformation shapes bacterial genomes, transmits antibiotic …

Most naturally competent bacteria tightly regulate the window of the competent state to
maximize their ecological fitness under specific conditions. Development of competence by …