Conotoxins: chemistry and biology
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …
and defense, providing the basis for survival and rapid diversification of the now estimated …
Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …
gated ion channels that mediate fast neurotransmission in the central and peripheral …
Cone snails: A big store of conotoxins for novel drug discovery
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …
700 species, have always been one of the focuses for new drug discovery. These venomous …
Crystal structures of protein-bound cyclic peptides
Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …
confers key advantages such as protection from proteolytic degradation, altered solubility …
What we have gained from ibogaine: α3β4 nicotinic acetylcholine receptor inhibitors as treatments for substance use disorders
For decades, ibogaine─ the main psychoactive alkaloid found in Tabernanthe iboga─ has
been investigated as a possible treatment for substance use disorders (SUDs) due to its …
been investigated as a possible treatment for substance use disorders (SUDs) due to its …
Marine origin ligands of nicotinic receptors: Low molecular compounds, peptides and proteins for fundamental research and practical applications
I Kasheverov, D Kudryavtsev, I Shelukhina, G Nikolaev… - Biomolecules, 2022 - mdpi.com
The purpose of our review is to briefly show what different compounds of marine origin, from
low molecular weight ones to peptides and proteins, offer for understanding the structure …
low molecular weight ones to peptides and proteins, offer for understanding the structure …
Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA …
M Zouridakis, A Papakyriakou, IA Ivanov… - Frontiers in …, 2019 - frontiersin.org
The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in
heteropentameric assemblies with α10. Accumulating data indicate the presence of three …
heteropentameric assemblies with α10. Accumulating data indicate the presence of three …
Neuronal nicotinic acetylcholine receptor modulators from cone snails
Marine cone snails are a large family of gastropods that have evolved highly potent venoms
for predation and defense. The cone snail venom has exceptional molecular diversity in …
for predation and defense. The cone snail venom has exceptional molecular diversity in …
Potency-and selectivity-enhancing mutations of conotoxins for nicotinic acetylcholine receptors can be predicted using accurate free-energy calculations
Nicotinic acetylcholine receptor (nAChR) subtypes are key drug targets, but it is challenging
to pharmacologically differentiate between them because of their highly similar sequence …
to pharmacologically differentiate between them because of their highly similar sequence …
α‐Conotoxins active at α3‐containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition
Neuronal α3‐containing nicotinic acetylcholine receptors (nAChRs) in the peripheral
nervous system (PNS) and non‐neuronal tissues are implicated in a number of severe …
nervous system (PNS) and non‐neuronal tissues are implicated in a number of severe …