Cancer-associated thrombosis (including venous thromboembolism (VTE) and arterial
events) is highly consequential for patients with cancer and is associated with worsened …

The interaction of tumor cells with platelets is a prerequisite for successful hematogenous
metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately …

Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

Patients with cancer have an increased risk of thromboembolism, which is the second
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …

Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins.
Many of them are expressed in myeloid cells and signal in response to pathogen-derived or …

Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid
cells, have gained increasing attention for their role in the fine tuning of both innate and …

Cancer-associated thrombosis is a leading cause of non-cancer death in cancer patients
and is comprised of both arterial and venous thromboembolism (VTE). There are multiple …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

Platelets are anucleate blood cells, long known to be critically involved in hemostasis and
thrombosis. In addition to their role in blood clots, increasing evidence reveals significant …