Determination of haplotype phase is becoming increasingly important as we enter the era of
large-scale sequencing because many of its applications, such as imputing low-frequency …

We present a survey of single-cell whole-genome amplification (WGA) methods, including
degenerate oligonucleotide–primed polymerase chain reaction (DOP-PCR), multiple …

Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of
genetic variation. We present a microfluidics-based, linked-read sequencing technology that …

Abstract The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but
genomically poorly explored phyla, the Mollusca. Here we report the sequencing and …

Many tools have been developed for haplotype assembly—the reconstruction of individual
haplotypes using reads mapped to a reference genome sequence. Due to increasing …

Improvement of variant calling in next-generation sequence data requires a comprehensive,
genome-wide catalog of high-confidence variants called in a set of genomes for use as a …

Advances in genome assembly and phasing provide an opportunity to investigate the
diploid architecture of the human genome and reveal the full range of structural variation …

We describe genome mapping on nanochannel arrays. In this approach, specific sequence
motifs in single DNA molecules are fluorescently labeled, and the DNA molecules are …

Haplotype-resolved genome sequencing enables the accurate interpretation of medically
relevant genetic variation, deep inferences regarding population history and non-invasive …

Here, we describe single-tube long fragment read (stLFR), a technology that enables
sequencing of data from long DNA molecules using economical second-generation …