Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

[HTML][HTML] Pancreatic stellate cell: Pandora's box for pancreatic disease biology

RR Bynigeri, A Jakkampudi, R Jangala… - World journal of …, 2017 - ncbi.nlm.nih.gov
Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation

KH Weylandt, CY Chiu, B Gomolka… - Prostaglandins & other …, 2012 - Elsevier
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have long been associated with
decreased inflammation and are also implicated in the prevention of tumorigenesis …

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

J Endo, M Sano, Y Isobe, K Fukuda, JX Kang… - Journal of Experimental …, 2014 - rupress.org
N-3 polyunsaturated fatty acids (PUFAs) have potential cardiovascular benefit, although the
mechanisms underlying this effect remain poorly understood. Fat-1 transgenic mice …

Omega‐3 polyunsaturated fatty acids: the way forward in times of mixed evidence

KH Weylandt, S Serini, YQ Chen, HM Su… - BioMed research …, 2015 - Wiley Online Library
Almost forty years ago, it was first hypothesized that an increased dietary intake of omega‐3
polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several …

Signaling and cytotoxic functions of 4-hydroxyalkenals

Y Riahi, G Cohen, O Shamni… - American Journal of …, 2010 - journals.physiology.org
The peroxidation of n-3 and n-6 polyunsaturated fatty acids (PUFAs) and of their
hydroperoxy metabolites is a complex process. It is initiated by free oxygen radical-induced …

High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition

J Bellenger, S Bellenger, A Bataille, KA Massey… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Because of confounding factors, the effects of dietary n-3 polyunsaturated fatty
acids (PUFA) on type 1 diabetes remain to be clarified. We therefore evaluated whether fat-1 …

Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune …

W Kong, JH Yen, D Ganea - Brain, behavior, and immunity, 2011 - Elsevier
Docosahexaenoic acid (DHA), the most abundant essential n− 3 polyunsaturated fatty acid
in the CNS, emerged recently together with eicosapentaenoic acid (EPA) and DHA/EPA …

Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained men

B Tartibian, BH Maleki, A Abbasi - Clinical Journal of Sport …, 2011 - journals.lww.com
Objective: To examine the effect of ingestion of omega-3 (N-3) fatty acids on the production
of interleukin (IL) 6, tumor necrosis factor (TNF) α, prostaglandin (PG) E 2, lactate …

[HTML][HTML] Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice

MJR Heerwagen, MS Stewart, BA de la Houssaye… - PloS one, 2013 - journals.plos.org
Maternal and pediatric obesity has risen dramatically over recent years, and is a known
predictor of adverse long-term metabolic outcomes in offspring. However, which particular …