[HTML][HTML] Extracellular-signal regulated kinase: A central molecule driving epithelial–mesenchymal transition in cancer
M Olea-Flores, MD Zuñiga-Eulogio… - International journal of …, 2019 - mdpi.com
Epithelial–mesenchymal transition (EMT) is a reversible cellular process, characterized by
changes in gene expression and activation of proteins, favoring the trans-differentiation of …
changes in gene expression and activation of proteins, favoring the trans-differentiation of …
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway
Abstract The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is de-regulated in a
variety of cancers due to mutations in receptor tyrosine kinases (RTKs), negative regulators …
variety of cancers due to mutations in receptor tyrosine kinases (RTKs), negative regulators …
[HTML][HTML] Targeting the MAPK/ERK and PI3K/AKT signaling pathways affects NRF2, Trx and GSH antioxidant systems in leukemia cells
E Jasek-Gajda, H Jurkowska, M Jasińska, GJ Lis - Antioxidants, 2020 - mdpi.com
The mitogen-activated protein kinase (MAPK)/extracellular signal kinase (ERK) and
phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signal transduction pathways …
phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signal transduction pathways …
[HTML][HTML] Network Pharmacology to Explore the Molecular Mechanisms of Prunella vulgaris for Treating Hashimoto's Thyroiditis
X Gan, L Zhong, F Shen, J Feng, Y Li, S Li… - Frontiers in …, 2021 - frontiersin.org
Purpose: Prunella vulgaris (PV), a traditional Chinese medicine, has been used to treat
patients with thyroid disease for centuries in China. The purpose of the present study was to …
patients with thyroid disease for centuries in China. The purpose of the present study was to …
[HTML][HTML] Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops.
Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway …
Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway …
Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of nonsmall cell …
RA Ward, MJ Anderton, P Bethel, J Breed, C Cook… - 2019 - ACS Publications
The RAS/MAPK pathway is a major driver of oncogenesis and is dysregulated in
approximately 30% of human cancers, primarily by mutations in the BRAF or RAS genes …
approximately 30% of human cancers, primarily by mutations in the BRAF or RAS genes …
[HTML][HTML] Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy
X Pan, J Pei, A Wang, W Shuai, L Feng, F Bu… - … Pharmaceutica Sinica B, 2022 - Elsevier
The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2
(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its …
(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its …
Isolates from Alpinia officinarum Hance attenuate LPS‐induced inflammation in HepG2: Evidence from in silico and in vitro studies
In an attempt to connect the legacy of centuries of invaluable knowledge from traditional
medicine and the current understanding to the molecular mechanism of diseases, we took …
medicine and the current understanding to the molecular mechanism of diseases, we took …
[HTML][HTML] Chrysophanol, physcion, hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2: in silico and …
Hepatitis is an inflammatory condition that can develop hepatocellular carcinoma.
Traditional medicine has always been the pillar of medical practice. However, it became less …
Traditional medicine has always been the pillar of medical practice. However, it became less …
Multistage screening reveals 3-substituted indolin-2-one derivatives as novel and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitors: implications to drug …
X Dou, H Huang, Y Li, L Jiang, Y Wang… - Journal of Medicinal …, 2019 - ACS Publications
Alzheimer's disease (AD) is one of the most challenging diseases around the world with no
effective clinical treatment. Previous studies have suggested c-Jun N-terminal kinase 3 …
effective clinical treatment. Previous studies have suggested c-Jun N-terminal kinase 3 …