Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

[HTML][HTML] Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

F Hagen, K Khayhan, B Theelen, A Kolecka… - Fungal genetics and …, 2015 - Elsevier
Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed
significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus …

Cryptococcus gattii infections

SCA Chen, W Meyer, TC Sorrell - Clinical microbiology reviews, 2014 - Am Soc Microbiol
Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by
modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans …

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

E Bielska, MA Sisquella, M Aldeieg, C Birch… - Nature …, 2018 - nature.com
Abstract The Pacific Northwest outbreak of cryptococcosis, caused by a near-clonal lineage
of the fungal pathogen Cryptococcus gattii, represents the most significant cluster of life …

Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States

EJ Byrnes III, W Li, Y Lewit, H Ma, K Voelz, P Ren… - PLoS …, 2010 - journals.plos.org
Cryptococcus gattii causes life-threatening disease in otherwise healthy hosts and to a
lesser extent in immunocompromised hosts. The highest incidence for this disease is on …

Anti-granulocyte-macrophage colony-stimulating factor autoantibodies are a risk factor for central nervous system infection by Cryptococcus gattii in otherwise …

T Saijo, J Chen, SCA Chen, LB Rosen, J Yi, TC Sorrell… - MBio, 2014 - Am Soc Microbiol
Cryptococcosis is caused by either Cryptococcus neoformans or C. gattii. While cryptococcal
meningoencephalitis is caused mostly by C. neoformans in immunocompromised patients …

Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

A Bojarczuk, KA Miller, R Hotham, A Lewis… - Scientific reports, 2016 - nature.com
Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

Cryptococcus neoformans: historical curiosity to modern pathogen

D Srikanta, FH Santiago‐Tirado, TL Doering - Yeast, 2014 - Wiley Online Library
The importance of the Basidiomycete Cryptococcus neoformans to human health has
stimulated its development as an experimental model for both basic physiology and …

Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review

MC Montoya, PM Magwene, JR Perfect - Journal of Fungi, 2021 - mdpi.com
The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …