Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

The biology of the human brain, and in particular the dynamic interactions between the
numerous cell types and regions of the central nervous system, has been difficult to study …

Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …

Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful
tools to study brain development and dysfunction. However, whether organoids can …

Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …

Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …

Meningiomas are the most common primary intracranial tumors, but the molecular drivers of
meningioma tumorigenesis are poorly understood. We hypothesized that investigating …