Human organs-on-chips for disease modelling, drug development and personalized medicine

DE Ingber - Nature Reviews Genetics, 2022 - nature.com
The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

N Sunildutt, P Parihar… - Frontiers in …, 2023 - frontiersin.org
The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

S Kumar, MK Shukla, AK Sharma, GK Jayaprakash… - MedComm, 2023 - Wiley Online Library
Cancer is a disease associated with complex pathology and one of the most prevalent and
leading reasons for mortality in the world. Current chemotherapy has challenges with …

Biogenic synthesis of zinc oxide nanorods for biomedical applications and photodegradation of Rhodamine B

SO Aisida, C Onwujiobi, I Ahmad, T Zhao… - Materials Today …, 2022 - Elsevier
The biogenic synthesis protocol of functional oxides from the extract of plants for biomedical
applications has gained more attention recently. This work involves a biogenic synthesis of …

Nanopriming Action of Microwave-Assisted Biofunctionalized ZnO Nanoparticles to Enhance the Growth under Moisture Stress in Vigna radiata

R Kalimuthu, K Meenachi Sellan, D Antony… - ACS …, 2023 - ACS Publications
Bare and stabilized zinc oxide nanoparticles (ZnO NPs) were prepared by a microwave-
assisted method and used as a priming agent to improve the morphological, physiological …

Experimental methods for the biological evaluation of nanoparticle-based drug delivery risks

RP Pandey, J Vidic, R Mukherjee, CM Chang - Pharmaceutics, 2023 - mdpi.com
Many novel medical therapies use nanoparticle-based drug delivery systems, including
nanomaterials through drug delivery systems, diagnostics, or physiologically active …

Sustainable fabrication of hybrid silver-copper nanocomposites (Ag‐CuO NCs) using Ocimum americanum L. as an effective regime against antibacterial, anticancer …

DB Manikandan, M Arumugam, A Sridhar… - Environmental …, 2023 - Elsevier
In this study, a sustainable fabrication of hybrid silver-copper oxide nanocomposites (Ag–
CuO NCs) was accomplished utilizing Ocimum americanum L. by one pot green chemistry …

Organ-on-chip systems as a model for nanomedicine

M Stavrou, N Phung, J Grimm, C Andreou - Nanoscale, 2023 - pubs.rsc.org
Nanomedicine is giving rise to increasing numbers of successful drugs, including cancer
treatments, molecular imaging agents, and novel vaccine formulations. However …