A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Transition states, analogues, and drug development

VL Schramm - ACS chemical biology, 2013 - ACS Publications
Enzymes achieve their transition states by dynamic conformational searches on the
femtosecond to picosecond time scale. Mimics of reactants at enzymatic transition states …

An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa

H Huang, X Shao, Y Xie, T Wang, Y Zhang… - Nature …, 2019 - nature.com
The virulence of Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is
regulated by many transcriptional factors (TFs) that control the expression of quorum …

RhlR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of Pseudomonas aeruginosa

RL Cruz, KL Asfahl, S Van den Bossche, T Coenye… - MBio, 2020 - Am Soc Microbiol
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection
in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and …

Targeting Quorum Sensing in Pseudomonas Aeruginosa Biofilms: Current and Emerging Inhibitors

TH Jakobsen, T Bjarnsholt, PØ Jensen… - Future …, 2013 - Taylor & Francis
Bacterial resistance to conventional antibiotics combined with an increasing
acknowledgement of the role of biofilms in chronic infections has led to a growing interest in …

Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells

SR Coleman, T Blimkie, R Falsafi… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Swarming surface motility is a complex adaptation leading to multidrug antibiotic resistance
and virulence factor production in Pseudomonas aeruginosa. Here, we expanded previous …

Novel therapeutic strategies for treating Pseudomonas aeruginosa infection

X Shao, Y Xie, Y Zhang, J Liu, Y Ding… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Persistent infections caused by the superbug Pseudomonas aeruginosa and its
resistance to multiple antimicrobial agents are huge threats to patients with cystic fibrosis as …

RpoN-dependent direct regulation of quorum sensing and the type VI secretion system in Pseudomonas aeruginosa PAO1

X Shao, X Zhang, Y Zhang, M Zhu, P Yang… - Journal of …, 2018 - Am Soc Microbiol
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen of humans,
particularly those with cystic fibrosis. As a global regulator, RpoN controls a group of …

Introducing differential RNA-seq mapping to track the early infection phase for Pseudomonas phage ɸKZ

L Wicke, F Ponath, L Coppens, M Gerovac… - RNA biology, 2021 - Taylor & Francis
As part of the ongoing renaissance of phage biology, more phage genomes are becoming
available through DNA sequencing. However, our understanding of the transcriptome …

Bactericidal, quorum quenching and anti-biofilm nanofactories: a new niche for nanotechnologists

BN Singh, null Prateeksha, DK Upreti… - Critical reviews in …, 2017 - Taylor & Francis
Despite several conventional potent antibacterial therapies, bacterial infections pose a
significant threat to human health because they are emerging as the leading cause of death …