A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence
D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …
Transition states, analogues, and drug development
VL Schramm - ACS chemical biology, 2013 - ACS Publications
Enzymes achieve their transition states by dynamic conformational searches on the
femtosecond to picosecond time scale. Mimics of reactants at enzymatic transition states …
femtosecond to picosecond time scale. Mimics of reactants at enzymatic transition states …
An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa
The virulence of Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is
regulated by many transcriptional factors (TFs) that control the expression of quorum …
regulated by many transcriptional factors (TFs) that control the expression of quorum …
RhlR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of Pseudomonas aeruginosa
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection
in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and …
in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and …
Targeting Quorum Sensing in Pseudomonas Aeruginosa Biofilms: Current and Emerging Inhibitors
TH Jakobsen, T Bjarnsholt, PØ Jensen… - Future …, 2013 - Taylor & Francis
Bacterial resistance to conventional antibiotics combined with an increasing
acknowledgement of the role of biofilms in chronic infections has led to a growing interest in …
acknowledgement of the role of biofilms in chronic infections has led to a growing interest in …
Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells
SR Coleman, T Blimkie, R Falsafi… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Swarming surface motility is a complex adaptation leading to multidrug antibiotic resistance
and virulence factor production in Pseudomonas aeruginosa. Here, we expanded previous …
and virulence factor production in Pseudomonas aeruginosa. Here, we expanded previous …
Novel therapeutic strategies for treating Pseudomonas aeruginosa infection
X Shao, Y Xie, Y Zhang, J Liu, Y Ding… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Persistent infections caused by the superbug Pseudomonas aeruginosa and its
resistance to multiple antimicrobial agents are huge threats to patients with cystic fibrosis as …
resistance to multiple antimicrobial agents are huge threats to patients with cystic fibrosis as …
RpoN-dependent direct regulation of quorum sensing and the type VI secretion system in Pseudomonas aeruginosa PAO1
X Shao, X Zhang, Y Zhang, M Zhu, P Yang… - Journal of …, 2018 - Am Soc Microbiol
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen of humans,
particularly those with cystic fibrosis. As a global regulator, RpoN controls a group of …
particularly those with cystic fibrosis. As a global regulator, RpoN controls a group of …
Introducing differential RNA-seq mapping to track the early infection phase for Pseudomonas phage ɸKZ
As part of the ongoing renaissance of phage biology, more phage genomes are becoming
available through DNA sequencing. However, our understanding of the transcriptome …
available through DNA sequencing. However, our understanding of the transcriptome …
Bactericidal, quorum quenching and anti-biofilm nanofactories: a new niche for nanotechnologists
Despite several conventional potent antibacterial therapies, bacterial infections pose a
significant threat to human health because they are emerging as the leading cause of death …
significant threat to human health because they are emerging as the leading cause of death …