The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Discovered in late 1960, azoles are heterocyclic compounds class which constitute the
largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical …

Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized
using both conventional method and ultrasound sonication (US) as an environmentally …

Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …

A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …

Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …

The need for novel heterocyclic compounds with robust biological action is a result of the
emergence of numerous pandemics and microbial resistance. To search antibacterial and …

Irradiation of N-enoxybenzotriazoles with blue LEDs in the presence of photosensitizers
productively rendered two reactive radical intermediates, that is, benzotriazolyl-and α …

A series of new coumarin based thiazoles were synthesized by the microwave irradiation of
thiocarbohydrazide, aldehydes and 3-(2-bromoacetyl) coumarins. Structures of all the …

In search of more potent and safe new antitubercular agents, here new 2-pyridinyl
substituted thiazolyl-5-aryl-1, 3, 4-oxadiazoles (6a–o), have been designed and synthesized …