[HTML][HTML] Nanopore sequencing technology, bioinformatics and applications

Y Wang, Y Zhao, A Bollas, Y Wang, KF Au - Nature biotechnology, 2021 - nature.com
Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

[PDF][PDF] Global anaemia reduction efforts among women of reproductive age: impact, achievement of targets and the way forward for optimizing efforts

World Health Organization - 2020 - apps.who.int
Anaemia is a global public health concern, afflicting adolescent girls, women of reproductive
age, pregnant women and children in low-and middle-income countries. 1 Reduction of …

Performance of neural network basecalling tools for Oxford Nanopore sequencing

RR Wick, LM Judd, KE Holt - Genome biology, 2019 - Springer
Background Basecalling, the computational process of translating raw electrical signal to
nucleotide sequence, is of critical importance to the sequencing platforms produced by …

Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen

CL Gorrie, M Mirčeta, RR Wick, LM Judd… - Nature …, 2022 - nature.com
Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …

Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Horizontal transfer of antibiotic resistance genes in clinical environments

NA Lerminiaux, ADS Cameron - Canadian journal of …, 2019 - cdnsciencepub.com
A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

[HTML][HTML] Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

KL Wyres, KE Holt - Current opinion in microbiology, 2018 - Elsevier
Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency
and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant …

Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

KL Wyres, RR Wick, LM Judd, R Froumine… - PLoS …, 2019 - journals.plos.org
Klebsiella pneumoniae has emerged as an important cause of two distinct public health
threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible …

Kaptive Web: user-friendly capsule and lipopolysaccharide serotype prediction for Klebsiella genomes

RR Wick, E Heinz, KE Holt… - Journal of clinical …, 2018 - Am Soc Microbiol
As whole-genome sequencing becomes an established component of the microbiologist's
toolbox, it is imperative that researchers, clinical microbiologists, and public health …