Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

The Aurora kinases (A, B, and C) are a family of three isoform serine/threonine kinases that
regulate mitosis and meiosis. The Chromosomal Passenger Complex (CPC), which contains …

Background & Aims Chromosomal instability (CIN) is a carcinogenesis event that promotes
metastasis and resistance to therapy by unclear mechanisms. Expression of the colon …

Aurora kinase B, one of the three members of the mammalian Aurora kinase family, is the
catalytic component of the chromosomal passenger complex, an essential regulator of …

Particulate matter (PM), a major component of outdoor air pollution, damages DNA and
increases the risk of cancer. Although the harmful effects of PM at the genomic level are …

The spindle assembly checkpoint (SAC) is a surveillance mechanism contributing to the
preservation of genomic stability by monitoring the microtubule attachment to, and/or the …

Background Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly
expressed in tumors. It has been hypothesized that Survivin facilitates carcinogenesis by …

Chromosomal instability (CIN) is characterized by an increased frequency of changes in
chromosome structure or number and is regarded as a hallmark of cancer. CIN plays a …

Background Activating mutations in KRAS are prevalent in lung cancer and have been
causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS …

Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset
of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a balance …