The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …

Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

The protein Klotho can significantly delay aging, so it has attracted widespread attention.
Abnormal downregulation of Klotho has been detected in several aging-related diseases …

Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors. Accumulating evidence …

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

Chronic kidney disease (CKD) is a growing problem among aging population, and the
number of individuals at risk of end stage renal disease is rising. Part of the reason lies in …

Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …