Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein
encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and …

Ginseng has been used in China as a superior medicinal material for thousands of years
that can nourish the five internal organs, calm the mind and benefit wisdom. Due to its anti …

The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest
known genetic risk factor for late-onset Alzheimer's disease. However, whether this single …

Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …

Background Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein
43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron …

We recently reported acute COVID-19 symptoms, clinical status, weight loss, multi-organ
pathological changes, and animal death in a murine hepatitis virus-1 (MHV-1) coronavirus …

The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …

Abstract Alzheimer's disease (AD), which mainly occurs in the elderly, is a
neurodegenerative disease with a hidden onset, which leads to progressive cognitive and …

Cognitive dysfunction is an important non-motor symptom in amyotrophic lateral sclerosis
(ALS) that has a negative impact on survival and caregiver burden. It shows a wide spectrum …

Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's
disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of …