Animals have evolved a multitude of signaling pathways that enable them to orchestrate
diverse physiological processes to tightly regulate systemic homeostasis. This signaling is …

A small number of signaling molecules, used reiteratively, control differentiation programs,
but the mechanisms that adapt developmental timing to environmental cues are less …

In arthropods, larger individuals tend to have more fat reserves, but data for many taxa are
still missing. For the vinegar fly Drosophila melanogaster, only few studies have provided …

Mammalian puberty and Drosophila metamorphosis, despite their evolutionary distance,
exhibit similar design principles and conservation of molecular components. In this …

In the body of multicellular organisms, macrophages play an indispensable role in
maintaining tissue homeostasis by removing old, apoptotic and damaged cells. In addition …

Trehalose is synthesized in insects through the trehalose 6‐phosphate synthase and
phosphatase (TPS/TPP) pathway. TPP dephosphorylates trehalose 6‐phosphate to release …

Organisms experience constant nutritional flux. Mechanisms at the interface of opposing
nutritional states—scarcity and surplus—enable organismal energy homeostasis …

In the present study, we investigated downstream pathways of cyclic adenosine
monophosphate (cAMP) signaling (which is related to prothoracicotropic hormone (PTTH) …

Defective nutrient storage and adipocyte enlargement (hypertrophy) are emerging features
of metabolic syndrome and type 2 diabetes. Within adipose tissues, how the cytoskeletal …

Critical weight (CW) attainment is a key life event in the development of holometabolous
insects including Drosophila melanogaster. It indicates that sufficient growth has occurred to …