Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's
disease. Under pathological conditions, Tau dissociates from axonal microtubules and …

Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …

The microtubule-associated protein tau accumulates in Alzheimer's and other fatal
dementias, which manifest when forebrain neurons die. Recent advances in understanding …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …

Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …