It has been 40 years since the first human-to-human heart transplant performed in South
Africa by Christiaan Barnard in December 1967. This achievement did not come as a …

Infectious complications remain a leading cause of morbidity and mortality after solid organ
transplantation (SOT), and largely depend on the net state of immunosuppression achieved …

Background. Long-term use of immunosuppressants is associated with significant morbidity
and mortality in transplant recipients. A simple whole blood assay that has US Food and …

Continuous antigen stimulation during chronic infection or malignancy can promote
functional T cell silencing, a phenomenon called T cell exhaustion. The prevalence and …

The aim of the present study was to estimate the effect of the perioperative administration of
probiotics in patients undergoing colorectal cancer (CRC) surgery. The study focused on a …

Background An immune function assay shows promise for identifying solid organ recipients
at risk for infection or rejection. The following randomized prospective study was designed to …

For modern approaches in precision medicine, fast and easy-to-use point-of-care
diagnostics (POCs) are essential. Digoxin was chosen as an example of a drug requiring …

BACKGROUND: Balancing immunosuppression to prevent rejection while minimizing
infection or drug toxicity risk is a major challenge in heart transplantation. Therapeutic drug …

BACKGROUND: Current monitoring systems of immunosuppression in solid-organ
transplant recipients are typically focused on prevention of clinical toxicities of …

Advances over the last decades have made renal transplantation an important therapy for
patients with end-stage renal disease, as the incidences of acute rejection and short-term …