Systems biology and metabolic modeling for cultivated meat: A promising approach for cell culture media optimization and cost reduction

S Gomez Romero, N Boyle - … in Food Science and Food Safety, 2023 - Wiley Online Library
The cultivated meat industry, also known as cell‐based meat, cultured meat, lab‐grown
meat, or meat alternatives, is a growing field that aims to generate animal tissues ex‐vivo in …

Current progress in long-term and continuous cell metabolite detection using microfluidics

J Shi, L Tong, W Tong, H Chen, M Lan, X Sun… - TrAC Trends in Analytical …, 2019 - Elsevier
Cellular metabolism involves complex sequences of controlled biochemical reactions and
many chemical compounds or metabolites. The quantification of these metabolites will …

Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

RAC Rabel, PV Marchioretto, EA Bangert, K Wilson… - Animals, 2023 - mdpi.com
Simple Summary With conventional breeding practices, even the best dairy/beef cows will
likely produce no more than half-a-dozen calves in their lifetimes; a crime, would you not …

Cell-free, embryo-specific sncRNA as a molecular biological bridge between patient fertility and IVF efficiency

AV Timofeeva, VV Chagovets, YS Drapkina… - International journal of …, 2019 - mdpi.com
Small noncoding RNAs (sncRNAs) are key regulators of the majority of human reproduction
events. Understanding their function in the context of gametogenesis and embryogenesis …

Does miRNA expression in the spent media change during early embryo development?

PD Rio, P Madan - Frontiers in Veterinary Science, 2021 - frontiersin.org
Distinct miRNA populations have been detected in the spent media of in-vitro culture
systems. However, profiling has been limited to media conditioned with blastocyst-stage …

Metabolites secreted by bovine embryos in vitro predict pregnancies that the recipient plasma metabolome cannot, and vice versa

E Gomez, N Canela, P Herrero, A Cereto, I Gimeno… - Metabolites, 2021 - mdpi.com
This work describes the use of mass spectrometry-based metabolomics as a non-invasive
approach to accurately predict birth prior to embryo transfer (ET) starting from embryo culture …

Parameters to identify good quality oocytes and embryos in cattle

C Wrenzycki - Reproduction, Fertility and Development, 2021 - CSIRO Publishing
Oocyte/embryo selection methodologies are either invasive or noninvasive and can be
applied at various stages of development from the oocyte to cleaved embryos and up to the …

Differential regulation of Hippo signaling pathway components between 8‐cell and blastocyst stages of bovine preimplantation embryogenesis

J Sharma, P Madan - Molecular Reproduction and …, 2022 - Wiley Online Library
The Hippo signaling pathway is an important regulator of lineage segregation
(trophectoderm and inner cell mass) during blastocyst formation in the mouse embryos …

The metabolic signature of in vitro produced bovine embryos helps predict pregnancy and birth after embryo transfer

I Gimeno, P García-Manrique, S Carrocera… - Metabolites, 2021 - mdpi.com
In vitro produced (IVP) embryos show large metabolic variability induced by breed, culture
conditions, embryonic stage and sex and gamete donors. We hypothesized that the birth …

Characterisation of the Hippo signalling pathway during bovine preimplantation embryo development

J Sharma, P Madan - Reproduction, Fertility and Development, 2020 - CSIRO Publishing
Blastocyst formation is an important milestone during preimplantation embryo development.
During murine preimplantation embryogenesis, the Hippo signalling pathway is known to …