[HTML][HTML] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
F Ardito, M Giuliani, D Perrone… - International …, 2017 - spandidos-publications.com
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
[HTML][HTML] Degradation of proteins by PROTACs and other strategies
Y Wang, X Jiang, F Feng, W Liu, H Sun - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …
AI-based protein structure prediction in drug discovery: impacts and challenges
M Schauperl, RA Denny - Journal of Chemical Information and …, 2022 - ACS Publications
Proteins are the molecular machinery of the human body, and their malfunctioning is often
responsible for diseases, making them crucial targets for drug discovery. The three …
responsible for diseases, making them crucial targets for drug discovery. The three …
Beyond proteolysis-targeting chimeric molecules: designing heterobifunctional molecules based on functional effectors
L Hua, Q Zhang, X Zhu, R Wang, Q You… - Journal of Medicinal …, 2022 - ACS Publications
In recent years, with the successful development of proteolysis-targeting chimeric molecules
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …
Advances in enrichment methods for mass spectrometry-based proteomics analysis of post-translational modifications
Post-translational modifications (PTMs) occur during or after protein biosynthesis and
increase the functional diversity of proteome. They comprise phosphorylation, acetylation …
increase the functional diversity of proteome. They comprise phosphorylation, acetylation …
Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes
P Vlastaridis, P Kyriakidou, A Chaliotis… - …, 2017 - academic.oup.com
Background Phosphorylation is the most frequent post-translational modification made to
proteins and may regulate protein activity as either a molecular digital switch or a rheostat …
proteins and may regulate protein activity as either a molecular digital switch or a rheostat …
de novo assembly and population genomic survey of natural yeast isolates with the Oxford Nanopore MinION sequencer
Abstract Background: Oxford Nanopore Technologies Ltd (Oxford, UK) have recently
commercialized MinION, a small single-molecule nanopore sequencer, that offers the …
commercialized MinION, a small single-molecule nanopore sequencer, that offers the …
Crosstalk between phosphorylation and O‐Glc NA cylation: friend or foe
A wide variety of protein post‐translational modifications (PTM s) decorate cellular proteins,
regulating their structure, interactions and ultimately their function. The density of co …
regulating their structure, interactions and ultimately their function. The density of co …
[PDF][PDF] Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …
[HTML][HTML] Protein phosphorylation and its role in the regulation of Annexin A2 function
Abstract Background Annexin A2 (AnxA2) is a multifunctional protein involved in
endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal …
endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal …