Naturally occurring plasmids come in different sizes. The smallest are less than a kilobase of
DNA, while the largest can be over three orders of magnitude larger. Historically, research …

Gene therapy is a therapeutic strategy of delivering foreign genetic material (encoding for an
important protein) into a patient's target cell to replace a defective gene. Nucleic acids are …

ABSTRACT DNA segregation ensures that cell offspring receive at least one copy of each
DNA molecule, or replicon, after their replication. This important cellular process includes …

Genetic tools are a prerequisite to engineer cellular factories for synthetic biology and
biotechnology. Methylorubrum extorquens AM1 is an important platform organism of a future …

While many bacteria divide by symmetric binary fission, some alphaproteobacteria have
strikingly asymmetric cell cycles, producing offspring that differs significantly in their …

The c ell c ycle-r egulated DNA m ethyltransferase CcrM is conserved in most
Alphaproteobacteria, but its role in bacteria with complex or multicentric genomes remains …

Studies of bacterial chromosomes and plasmids indicate that their replication initiator
proteins bind to origins of replication at many double-stranded sites and also at AT-rich …

Vibrio cholerae, the pathogenic bacterium that causes cholera, has two chromosomes
(Chr1, Chr2) that replicate in a well-orchestrated sequence. Chr2 initiation is triggered only …

Methylation of specific DNA sequences is ubiquitous in bacteria and has known roles in
immunity and regulation of cellular processes, such as the cell cycle. Here, we explored …

Members of the alphaproteobacterial order Rhodobacterales are metabolically diverse and
highly abundant in the ocean. They are becoming increasingly interesting for marine …