Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …

Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

Lymphatic vessels collect interstitial fluid that has extravasated from blood vessels and
return it to the circulatory system. Another important function of the lymphatic network is to …

Immune regulation by cytokines is crucial in maintaining immune homeostasis, promoting
responses to infection, resolving inflammation, and promoting immunological memory …

The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-
tumor immunity. Primary tumor irradiation promotes 'radio-vaccination'by enhancing the …

Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells that act to
bridge innate and adaptive immunity. DCs are critical in mounting effective immune …

Although cancer vaccine-based immunotherapy holds great potential for cancer treatment,
tumor-induced dendritic cell (DC) dysfunction remains to be the major obstacle for …

The exploitation of T cell-based immunotherapies and immune checkpoint blockade for
cancer treatment has dramatically shifted oncological treatment paradigms and broadened …

Cancer immunotherapy is emerging as a promising treatment modality that suppresses and
eliminates tumors by re-activating and maintaining the tumor-immune cycle, and further …

Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading
cause of cancer-related deaths worldwide. Locally advanced and metastatic disease exhibit …