Subtypes of atopic dermatitis: From phenotype to endotype

Y Tokura, S Hayano - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is a heterogenous disorder and can be classified into
different types. Stratification of subtypes may enable personalized medicine approaches. AD …

Allergy: Mechanistic insights into new methods of prevention and therapy

CA Akdis, M Akdis, SD Boyd, V Sampath… - Science Translational …, 2023 - science.org
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here,
we review the etiology and pathophysiology of allergic diseases, including the role of the …

Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial

HO Skjerven, A Lie, R Vettukattil, EM Rehbinder… - The Lancet, 2022 - thelancet.com
Background Primary prevention of food allergy by early introduction of allergenic foods
seems promising. We aimed to determine whether early food introduction or the application …

Early initiation of short‐term emollient use for the prevention of atopic dermatitis in high‐risk infants—The STOP‐AD randomised controlled trial

C Ní Chaoimh, D Lad, C Nico, GJ Puppels… - Allergy, 2023 - Wiley Online Library
Background Protecting the skin barrier in early infancy may prevent atopic dermatitis (AD).
We investigated if daily emollient use from birth to 2 months reduced AD incidence in high …

Targeting skin barrier function in atopic dermatitis

EH van den Bogaard, PM Elias, E Goleva… - The Journal of Allergy …, 2023 - Elsevier
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general
population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of …

Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis

SG Danby, PV Andrew, RN Taylor… - Clinical and …, 2022 - academic.oup.com
Background Eczema (atopic dermatitis; AD) is a very common itchy skin condition affecting 1
in 5 children and up to 1 in 10 adults worldwide. The skin of eczema sufferers is prone to …

Emollients for prevention of atopic dermatitis: 5‐year findings from the BEEP randomized trial

LE Bradshaw, LA Wyatt, SJ Brown, RH Haines… - Allergy, 2023 - Wiley Online Library
Background The effectiveness of emollients for preventing atopic dermatitis/eczema is
controversial. The Barrier Enhancement for Eczema Prevention trial evaluated the effects of …

A pragmatic approach to infant feeding for food allergy prevention

V McWilliam, C Venter, M Greenhawt… - Pediatric Allergy and …, 2022 - Wiley Online Library
Early introduction of allergenic foods into an infant's diet is currently the most promising
strategy to prevent food allergy, with infant guidelines around the world shifting from …

Role of skin management in the prevention of atopic dermatitis and food allergy

EH Tham, K Yamamoto‐Hanada… - Pediatric Allergy and …, 2024 - Wiley Online Library
Food allergy is postulated to originate from cutaneous sensitization through a disrupted skin
barrier, particularly in atopic dermatitis (AD). Strategies for food allergy prevention currently …

From skin barrier dysfunction to systemic impact of atopic dermatitis: implications for a precision approach in dermocosmetics and medicine

L Maintz, T Bieber, HD Simpson… - Journal of Personalized …, 2022 - mdpi.com
Atopic dermatitis (AD) affects up to 20% of children and is considered the starting point of the
atopic march with the development of food allergy, asthma, and allergic rhinitis. The …