Mechanisms of autoantibody-induced pathology
RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
Myasthenia gravis: the role of complement at the neuromuscular junction
JF Howard Jr - Annals of the New York Academy of Sciences, 2018 - Wiley Online Library
Generalized myasthenia gravis (gMG) is a rare autoimmune disorder characterized by
skeletal muscle weakness caused by disrupted neurotransmission at the neuromuscular …
skeletal muscle weakness caused by disrupted neurotransmission at the neuromuscular …
Muscle and neuronal nicotinic acetylcholine receptors: structure, function and pathogenicity
D Kalamida, K Poulas, V Avramopoulou… - The FEBS …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …
Nicotinic acetylcholine receptors in health and disease
J Lindstrom - Molecular neurobiology, 1997 - Springer
Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation
channels that form the predominant excitatory neurotransmitter receptors on muscles and …
channels that form the predominant excitatory neurotransmitter receptors on muscles and …
Acetylcholine receptors and myasthenia
JM Lindstrom - Muscle & Nerve: Official Journal of the …, 2000 - Wiley Online Library
Much progress has been made in the 26 years since initial studies of the first purified
acetylcholine receptors (AChRs) led to the discovery that an antibody‐mediated …
acetylcholine receptors (AChRs) led to the discovery that an antibody‐mediated …
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors
M Tomizawa, DL Lee, JE Casida - Journal of agricultural and food …, 2000 - ACS Publications
The favorable selective toxicity of neonicotinoid insecticides (represented here by
imidacloprid, thiacloprid, and a nitromethylene analogue) for insects versus mammals is not …
imidacloprid, thiacloprid, and a nitromethylene analogue) for insects versus mammals is not …
Assembly of human neuronal nicotinic receptor α5 subunits with α3, β2, and β4 subunits
F Wang, V Gerzanich, GB Wells, R Anand… - Journal of Biological …, 1996 - ASBMB
Nicotinic acetylcholine receptors formed from combinations of α3, β2, β4, and α5 subunits
are found in chicken ciliary ganglion neurons and some human neuroblastoma cell lines …
are found in chicken ciliary ganglion neurons and some human neuroblastoma cell lines …
Neuronal nicotinic acetylcholine receptors
J Lindstrom - Ion channels, 1996 - Springer
Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs)
evolved out of studies of muscle AChRs. This review will begin with a brief summary of …
evolved out of studies of muscle AChRs. This review will begin with a brief summary of …
Anatomy of the antigenic structure of a large memberane autoantigen, the muscle‐type nicotinic acetylcholine receptor
SJ Tzartos, T Barkas, MT Cung… - Immunological …, 1998 - Wiley Online Library
The neuromuscular junction nicotinic acetylcholine receptor (AChR), a pentameric
membrane glycoprotein, is the autoantigen involved in the autoimmune disease myasthenia …
membrane glycoprotein, is the autoantigen involved in the autoimmune disease myasthenia …
Human α4β2 acetylcholine receptors formed from linked subunits
Y Zhou, ME Nelson, A Kuryatov, C Choi… - Journal of …, 2003 - Soc Neuroscience
We prepared concatamers of α4 and β2 subunits for human nicotinic acetylcholine receptors
(AChRs), in which the C terminus of α4 was linked to the N terminus of β2, or vice versa, via …
(AChRs), in which the C terminus of α4 was linked to the N terminus of β2, or vice versa, via …