The mammalian CNS is an intricate and fragile structure, which on one hand is open to
change in order to store information, but on the other hand is vulnerable to damage from …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

Brains of Alzheimer's disease patients are characterized by the presence of amyloid plaques
and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial role …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

The activation of the NLRP3 inflammasome signaling pathway plays an important role in the
neuroinflammation in Alzheimer's disease (AD). In this study, we investigated the effects of …

Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain
homeostasis. Glial cells play a central role in orchestrating these neuroinflammation …

Inflammasome activation in the central nervous system occurs in both health and disease.
Inflammasomes are cytosolic protein complexes that sense specific infectious or host stimuli …

Pyroptosis is an inflammatory form of cell death executed by transmembrane pore-forming
proteins known as gasdermins and can be activated in an inflammasome-dependent or …