Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …

Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

Immune checkpoint inhibitors are associated with immune-related adverse events (irAEs),
including arthritis (arthritis-irAE). Management of arthritis-irAE is challenging because …

T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive
immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLO …

T follicular helper (Tfh) cells provide signals to initiate and maintain the germinal center (GC)
reaction and are crucial for the generation of robust, long-lived antibody responses, but how …

Objective A novel population of B helper cells, phenotypically CD4+ CXCR5− PD-1hi, has
been described in the synovial tissues and peripheral blood of seropositive RA patients, and …

Rheumatoid arthritis (RA) is a chronic inflammatory synovitis-based systemic disease
characterized by invasive joint inflammation and synovial hyperplasia, which can lead to …