Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila
melanogaster has proven to be a powerful model for the study of innate immunity. Early work …

Metastasis is a crucial hallmark of cancer progression, which involves numerous factors
including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal …

Cell–cell interactions define a quintessential aspect of multicellular development. Metazoan
morphogenesis depends on a handful of fundamental, conserved cellular interaction …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

Although cellular tumor-suppression mechanisms are widely studied, little is known about
mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in …

Simple Summary Notch signaling has been shown to mediate treatment resistance and
support cancer stem cells (CSC) in luminal endocrine-resistant and triple negative breast …

The members of myocyte Enhancer Factor 2 (MEF2) protein family was previously believed
to function in the development of heart and muscle. Recent reports indicate that they are …

Mitochondrial morphology is remodeled by continuous dynamic cycles of fission and fusion.
Emerging data have shown that the disturbance of balance between mitochondrial fission …

Various studies have evaluated the significance of Notch1 expression in breast cancer, but
the results have ever been disputed. By using 21 studies involving 3867 patients, this meta …