Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

The treatment of restless legs syndrome and periodic limb movement disorder

W Hening, R Allen, C Earley, C Kushida, D Picchietti… - Sleep, 1999 - academic.oup.com
A task force consisting of six authors reviewed the published literature on the therapy of the
restless legs syndrome or periodic limb movements in sleep available in indices through …

Prevalence of restless legs syndrome and periodic limb movement disorder in the general population

MM Ohayon, T Roth - Journal of psychosomatic research, 2002 - Elsevier
Background: Periodic limb movement disorder (PLMD) and restless legs syndrome (RLS)
are two sleep disorders characterized by abnormal leg movements and are responsible for …

Sex and the risk of restless legs syndrome in the general population

K Berger, J Luedemann, C Trenkwalder… - Archives of internal …, 2004 - jamanetwork.com
Background Restless legs syndrome (RLS) is characterized by the desire to move the limbs
associated with paresthesias of the legs, a motor restlessness, an intensification of …

Epidemiology of restless legs symptoms in adults

B Phillips, T Young, L Finn, K Asher… - Archives of internal …, 2000 - jamanetwork.com
Background Restless legs syndrome (RLS) is a disorder characterized by sleep-disrupting
unpleasant leg sensations, often accompanied by daytime behavioral problems. Treatment …

Restless legs symptoms among incident dialysis patients: association with lower quality of life and shorter survival

ML Unruh, AS Levey, C D'Ambrosio, NE Fink… - American journal of …, 2004 - Elsevier
Background: Symptoms of restless legs are common among patients treated with long-term
hemodialysis. We investigated the relation between symptoms of restless legs, quality of life …

Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis

J Takaki, T Nishi, M Nangaku, H Shimoyama… - American journal of …, 2003 - Elsevier
[Formula: see text]: The pathogenesis of restless legs syndrome (RLS) is still unclear. The
purpose of this study is to determine relationships of the presence of RLS in uremic patients …

A randomized controlled study of pergolide in patients with restless legs syndrome

TC Wetter, K Stiasny, J Winkelmann, A Buhlinger… - Neurology, 1999 - AAN Enterprises
Background: Open clinical trials indicate that low doses of pergolide, a long-acting D1 and
D2 dopamine agonist, lead to a reduction in the symptoms of restless legs syndrome (RLS) …

A crossover study of gabapentin in treatment of restless legs syndrome among hemodialysis patients

ML Thorp, CD Morris, SP Bagby - American Journal of Kidney Diseases, 2001 - Elsevier
Restless legs syndrome (RLS) is a common entity affecting hemodialysis patients. Although
the cause of RLS remains unclear, a number of therapies have been used successfully to …

Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review

KE Innes, TK Selfe, P Agarwal - Sleep medicine reviews, 2012 - Elsevier
Restless legs syndrome (RLS) is a distressing sleep and sensorimotor disorder that affects a
large percentage of adults in the western industrialized world and is associated with …