Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …

Organotypic tissue slice culture is established from animal or patient tissues and cultivated
in an in vitro ecosystem. This technique has made countless contributions to anticancer drug …

Objective Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive
cellular therapy have had limited success in patients with microsatellite stable colorectal …

Purpose: Pancreatic ductal adenocarcinoma (PDA) is rarely cured, and single-agent
immune checkpoint inhibition has not demonstrated clinical benefit despite the presence of …

Defining the principles of T cell migration in structurally and mechanically complex tumor
microenvironments is critical to understanding escape from antitumor immunity and …

There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC).
While palliative chemotherapy offers a survival benefit to most patients, nearly all will …

Background Though currently approved immunotherapies, including chimeric antigen
receptor T cells and checkpoint blockade antibodies, have been successfully used to treat …

Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its
microenvironment is modified to provide a niche that is conducive for colorectal cancer cell …

Organotypic tumor slices represent a physiologically-relevant culture system for studying the
tumor microenvironment. Systematic characterization of the tumor slice culture system will …

Pancreatic ductal adenocarcinoma (PDAC) is associated with extensive dysregulation of the
epigenome and epigenetic regulators, such as bromodomain and extraterminal motif (BET) …