Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying
individuals at low and high risk of developing CRC, as they can then be offered targeted …

Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

A review of the epidemiological literature linking pesticides to cancers in occupational
studies worldwide was conducted, with particular focus on those articles published after the …

BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …

We conducted a multi-stage, genome-wide association study of bladder cancer with a
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …

Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To
identify common low-penetrance ovarian cancer susceptibility genes, we conducted a …

Recent genome‐wide association studies reported strong and reproducible associations of
multiple genetic variants in a large “gene‐desert” region of chromosome 8q24 with …