The mechanical role of the cervix in pregnancy

KM Myers, H Feltovich, E Mazza, J Vink, M Bajka… - Journal of …, 2015 - Elsevier
Appropriate mechanical function of the uterine cervix is critical for maintaining a pregnancy
to term so that the fetus can develop fully. At the end of pregnancy, however, the cervix must …

[PDF][PDF] Cervical remodeling in term and preterm birth: insights from an animal model

M Mahendroo - Reproduction, 2012 - scholar.archive.org
Proper cervical function is essential for a normal pregnancy and birth to occur.
Understanding the mechanisms that take place in normal pregnancy will allow a better …

Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition

R Menon, EA Bonney, J Condon… - Human reproduction …, 2016 - academic.oup.com
The signals and mechanisms that synchronize the timing of human parturition remain a
mystery and a better understanding of these processes is essential to avert adverse …

Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy

M House, DL Kaplan, S Socrate - Seminars in perinatology, 2009 - Elsevier
In normal pregnancy, the cervix maintains its shape during a period of substantial fetal and
uterine growth. Hence, maintenance of biomechanical integrity is an important aspect of …

Quantitative evaluation of collagen crosslinks and corresponding tensile mechanical properties in mouse cervical tissue during normal pregnancy

K Yoshida, H Jiang, MJ Kim, J Vink, S Cremers, D Paik… - PloS one, 2014 - journals.plos.org
The changes in the mechanical integrity of the cervix during pregnancy have implications for
a successful delivery. Cervical collagens are known to remodel extensively in mice with …

Cervical etiology of spontaneous preterm birth

J Vink, H Feltovich - Seminars in Fetal and Neonatal Medicine, 2016 - Elsevier
The cervix functions as a barrier between the uterus and vagina and keeps the uterus closed
until term so that the fetus can develop. For delivery the cervix must soften and dilate, and …

Evaluation of cervical stiffness during pregnancy using semiquantitative ultrasound elastography

E Hernandez‐Andrade, SS Hassan… - … in Obstetrics & …, 2013 - Wiley Online Library
Objective To evaluate cervical stiffness during pregnancy using ultrasound‐derived
elastography, a method used to estimate the average tissue displacement (strain) within a …

PGE2 vs PGF2α in human parturition

W Li, J Lu, C Zhang, W Wang, H Ying, L Myatt, K Sun - Placenta, 2021 - Elsevier
Abstract Prostaglandin E2 (PGE2) and F2α (PGF2α) are the two most prominent prostanoids
in parturition. They are involved in cervical ripening, membrane rupture, myometrial …

Immunobiology of cervix ripening

SM Yellon - Frontiers in Immunology, 2020 - frontiersin.org
The cervix is the essential gatekeeper for birth. Incomplete cervix remodeling contributes to
problems with delivery at or post-term while preterm birth is a major factor in perinatal …

Mechanics of cervical remodelling: insights from rodent models of pregnancy

K Yoshida, C Jayyosi, N Lee… - Interface …, 2019 - royalsocietypublishing.org
The uterine cervix undergoes a complex remodelling process during pregnancy,
characterized by dramatic changes in both extracellular matrix (ECM) structure and …