Physical modeling of multivalent interactions in the nuclear pore complex

LK Davis, A Šarić, BW Hoogenboom, A Zilman - Biophysical Journal, 2021 - cell.com
In the nuclear pore complex, intrinsically disordered proteins (FG Nups), along with their
interactions with more globular proteins called nuclear transport receptors (NTRs), are vital …

Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics

LK Davis, IJ Ford, A Šarić, BW Hoogenboom - Physical Review E, 2020 - APS
In the nuclear pore complex, intrinsically disordered nuclear pore proteins (FG Nups) form a
selective barrier for transport into and out of the cell nucleus, in a way that remains poorly …

Aging of thermoreversible gel of associating polymers

K Singh, Y Rabin - Macromolecules, 2020 - ACS Publications
We performed Langevin dynamics simulations of amphiphilic polymers that contain strongly
associating stickers connected by long soluble chain segments. We explored the aging of a …

[HTML][HTML] Sequence effects on internal structure of droplets of associative polymers

K Singh, Y Rabin - Biophysical Journal, 2021 - cell.com
Intrinsically disordered proteins (IDPs) can form liquid-like membraneless organelles, gels,
and fibers in cells and in vitro. In this study, we propose a simple model of IDPs as …

Computational Biophysical Model of the Nuclear Pore Complex: Insights from Statistical and Big-Data Analysis

R Moussavi-Baygi - 2017 - escholarship.org
The nuclear pore complexes (NPCs) are the sole channels known on the nuclear envelope
in eukaryotes through which nucleocytoplasmic traffic is selectively and efficiently …