Reactive oxygen species (ROS)-responsive prodrugs, probes, and theranostic prodrugs: applications in the ROS-related diseases

P Wang, Q Gong, J Hu, X Li… - Journal of Medicinal …, 2020 - ACS Publications
Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Diet influences the functions of the human intestinal microbiome

M De Angelis, I Ferrocino, FM Calabrese… - Scientific reports, 2020 - nature.com
Gut microbes programme their metabolism to suit intestinal conditions and convert dietary
components into a panel of small molecules that ultimately affect host physiology. To unveil …

Recent advances in nanoscale metal–organic frameworks towards cancer cell cytotoxicity: an overview

PD Harvey, J Plé - Journal of inorganic and organometallic polymers and …, 2021 - Springer
The fight against cancer has always been a prevalent research topic. Nanomaterials have
the ability to directly penetrate cancer cells and potentially achieve minimally invasive …

Construction of an RNA-binding protein-related prognostic model for pancreatic adenocarcinoma based on TCGA and GTEx databases

X Wen, Z Shao, S Chen, W Wang, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target
mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA …

Repositioning and investigational drugs for Zika virus infection treatment: a patent review

S G. Viveiros Rosa, IM Fierro… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Zika virus (ZIKV) is transmitted to humans throughout bites of Aedes
mosquitoes. ZIKV infection may be asymptomatic in most cases, but it may cause fever …

Purification, characterization and cytotoxic properties of a bacterial RNase

R Kumar, S Katwal, B Sharma, A Sharma, S Puri… - International Journal of …, 2021 - Elsevier
Abstract An RNase produced by Bacillus safensis RB-5 was purified up to 22.32-fold by
successive techniques of salting out, DEAE-anion exchange and gel permeation (Sephadex …

[PDF][PDF] Ribonuclease as anticancer therapeutics

SS Kanwar, R Kumar - Enz Eng, 2017 - researchgate.net
Ribonucleases (RNases) are small molecules which are highly cytotoxic in nature. They
catalyse the degradation of RNA into smaller molecules rapidly in an unprotected …

Stability of therapeutic enzymes: Challenges and recent advances

S Ghosh, S Alam, AS Rathore, SK Khare - Therapeutic Enzymes: Function …, 2019 - Springer
Enzymes are biocatalysts that have found profound applications in the current
biotherapeutic industry and play a crucial role in diagnosis, prevention, and biochemical …

The changes of NO level and RNase activity in tumor tissue accompanying the progression of prostate cancer

АP Burlaka, SV Virko, VM Grygorenko… - Experimental …, 2022 - exp-oncology.com.ua
Aim: To assess the inducible NO-synthase activity and the total RNase activity in tissue
samples and blood neutrophils of the patients with prostate intraepithelial neoplasia (PIN) …

Expressional profiling and clinical relevance of RNase κ in prostate cancer: a novel indicator of favorable progression-free survival

A Kladi-Skandali, K Mavridis, A Scorilas… - Journal of Cancer …, 2018 - Springer
Purpose Considering the unmet need for novel molecular tumor markers capable of
improving prostate cancer (CaP) patients' management along with the fruitful results …