The industrial production of complex biopharmaceuticals using recombinant mammalian cell
lines is still mainly built on a quality by testing approach, which is represented by fixed …

The use of spectroscopic sensors for bioprocess monitoring is a powerful tool within the
process analytical technology (PAT) initiative of the US Food and Drug Administration …

Real-time analytical tools to monitor bioprocess and fermentation in biological and food
applications are becoming increasingly important. Traditional laboratory-based analyses …

The metabolic activity of microbial communities plays a primary role in the flow of essential
nutrients throughout the biosphere. Molecular genetics has revealed the metabolic …

This contribution includes an investigation of the applicability of Raman spectroscopy as a
PAT analyzer in cyclic production processes of a potential Malaria vaccine with Pichia …

Raman spectroscopy, a robust and non‐invasive analytical method, has demonstrated
significant potential for monitoring biopharmaceutical production processes. Its ability to …

Recent advances in sensor development and miniaturization offer new possibilities to
monitor and control bioprocesses. Specific requirements for anaerobic processes in terms of …

The Raman-effect was discovered almost 90 years ago. It took a long time until the
importance of Raman spectroscopy was fully understood and accepted for process industrial …

摘要针对近红外光谱在线监测软件算法模型扩展功能受限和对外服务能力受限的问题,
论文设计出一种预测精准且开放服务能力强的近红外在线葡萄糖浓度监测系统. 首先 …

The present work investigated the applicability of in-line and off-line Raman spectroscopy for
the quantification of glycerol, methanol, cell density, and total protein in fed-batch …